Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22

Appropriate immune responses and mucosal barrier functions are required for the maintenance of intestinal homeostasis. Defects in this defense system may lead to inflammatory disorders such as inflammatory bowel disease. Downstream of tyrosine kinases 1 (Dok-1) and its closest homolog, Dok-2, are pr...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-09, Vol.478 (1), p.135-142
Hauptverfasser:	Waseda, Masazumi, Arimura, Sumimasa, Shimura, Eri, Nakae, Susumu, Yamanashi, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals CELL PROLIFERATION Colitis Colitis - metabolism Colon - metabolism DEXTRAN Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Dok Down-Regulation DSS EPITHELIUM HOMEOSTASIS INFLAMMATION Interleukin-17 - metabolism Interleukin-22 Interleukins - metabolism Intestinal Mucosa - metabolism KNOCK-OUT REACTIONS LARGE INTESTINE LYMPHOKINES MICE Mice, Inbred C57BL Mice, Knockout Phosphoproteins - genetics Phosphoproteins - metabolism PHOSPHOTRANSFERASES RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism SODIUM SULFATES Th17 cytokines TYROSINE
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