MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer

The dysfunction of DNA damage repair (DDR) pathway contributes to tumorigenesis and drug-resistance in cancer. MUS81 is a member of the conserved xeroderma pigmentosum group F (XPF) family protein of endonucleases, which is important to the DDR pathway. However, the role of MUS81 in the development...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-08, Vol.476 (4), p.493-500
Hauptverfasser:	Xie, Suhong, Zheng, Hui, Wen, Xuemei, Sun, Jiajun, Wang, Yanchun, Gao, Xiang, Guo, Lin, Lu, Renquan
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES animal ovaries ANIMAL TISSUES antineoplastic activity Antineoplastic Agents - pharmacology BIOPSY carcinogenesis Case-Control Studies CELL CYCLE Cell Line, Tumor CELL PROLIFERATION cell senescence cisplatin Cisplatin - pharmacology COLONY FORMATION CONGENITAL DISEASES Cystadenocarcinoma, Serous - drug therapy Cystadenocarcinoma, Serous - metabolism Cystadenocarcinoma, Serous - pathology DNA DAMAGES DNA repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation drug resistance Drug Resistance, Neoplasm Drug sensitivity ENDONUCLEASES Endonucleases - genetics Endonucleases - metabolism epithelial cells Female growth and development HEREDITARY DISEASES Humans Immunohistochemistry INHIBITION Middle Aged MUS81 neoplasm cells NEOPLASMS Ovarian cancer ovarian development ovarian neoplasms Ovarian Neoplasms - drug therapy Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology OVARIES patients photosensitivity disorders POLYMERASE CHAIN REACTION Proliferation quantitative polymerase chain reaction reverse transcriptase polymerase chain reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Senescence SKIN DISEASES Tumor Stem Cell Assay
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