Hypoxic stress up-regulates Kir2.1 expression and facilitates cell proliferation in brain capillary endothelial cells

The blood-brain barrier (BBB) is mainly composed of brain capillary endothelial cells (BCECs), astrocytes and pericytes. Brain ischemia causes hypoxic encephalopathy and damages BBB. However, it remains still unclear how hypoxia affects BCECs. In the present study, t-BBEC117 cells, an immortalized b...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-08, Vol.476 (4), p.386-392
Hauptverfasser:	Yamamura, Hideto, Suzuki, Yoshiaki, Yamamura, Hisao, Asai, Kiyofumi, Imaizumi, Yuji
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES [Ca2+]i anaerobic conditions Animals ANOXIA astrocytes barium BARIUM IONS BBB BCECs BIOMEDICAL RADIOGRAPHY BLOOD BLOOD-BRAIN BARRIER BRAIN Brain - cytology Brain endothelial cells calcium Calcium - metabolism CAPILLARIES CATTLE Cell Hypoxia - physiology CELL PROLIFERATION Cells, Cultured CRAC encephalopathy endothelial cells Endothelial Cells - metabolism gene expression gene expression regulation Hypoxia image analysis ISCHEMIA Kir2.1 channel membrane potential Membrane Potentials MESSENGER-RNA oxygen POLYMERASE CHAIN REACTION potassium Potassium Channels, Inwardly Rectifying - genetics Potassium Channels, Inwardly Rectifying - metabolism POTASSIUM IONS quantitative polymerase chain reaction RECEPTORS RECTIFIERS RMP SOC SOCE Store-operated Ca2+ entry Stress, Physiological transient receptor potential channels Up-Regulation Western blotting
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