Epigenetic identification of ZNF545 as a functional tumor suppressor in multiple myeloma via activation of p53 signaling pathway

The KRAB–zinc-finger protein ZNF545 was recently identified as a potential suppressor gene in several tumors. However, the regulatory mechanisms of ZNF545 in tumorigenesis remain unclear. In this study, we investigated the expression and roles of ZNF545 in multiple myeloma (MM). ZNF545 was frequentl...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-06, Vol.474 (4), p.660-666
Hauptverfasser:	Fan, Yu, Zhan, Qian, Xu, Hongying, Li, Lili, Li, Chen, Xiao, Qian, Xiang, Shili, Hui, Tianli, Xiang, Tingxiu, Ren, Guosheng
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS BIOLOGICAL MARKERS Biomarkers, Tumor - genetics BONE MARROW CELL PROLIFERATION DIAGNOSIS Epigenesis, Genetic Gene Expression Regulation, Neoplastic - genetics GENE REGULATION Genes, Tumor Suppressor Genetic Markers - genetics Humans METHYLATION Multiple myeloma Multiple Myeloma - genetics NEOPLASMS Nuclear Proteins - genetics PROMOTERS PROTEINS SKELETON THERAPY Transcriptional Activation - genetics Tumor suppressor Tumor Suppressor Protein p53 - genetics Tumor Suppressor Proteins - genetics ZNF545
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