Artesunate inhibits adipogeneis in 3T3-L1 preadipocytes by reducing the expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3

Differentiation of preadipocyte, also called adipogenesis, leads to the phenotype of mature adipocyte. However, excessive adipogenesis is closely linked to the development of obesity. Artesunate, one of artemisinin-type sesquiterpene lactones from Artemisia annua L., is known for anti-malarial and a...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-05, Vol.474 (1), p.220-225
1. Verfasser:	Jang, Byeong-Churl
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells 60 APPLIED LIFE SCIENCES ADENOSINE Adipogenesis Adipogenesis - drug effects Adipogenesis - physiology Animals Artemisia annua Artemisinins - administration & dosage Artesunate C/EBP-α CARBOXYLIC ACIDS CATTLE CCAAT-Enhancer-Binding Protein-alpha - metabolism Cell Differentiation - drug effects Cell Differentiation - physiology CHEMILUMINESCENCE CONCENTRATION RATIO FAS fas Receptor - metabolism LACTONES LEPTIN MESSENGER-RNA METABOLIC DISEASES Mice Perilipin-1 - metabolism PHENOTYPE PHOSPHORYLATION Phosphorylation - drug effects PPAR gamma - metabolism PPAR-γ RECEPTORS STAT-3 STAT3 Transcription Factor - metabolism TRANSCRIPTION TRIGLYCERIDES
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