NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-induced endoplasmic reticulum protein

Homocysteine-induced endoplasmic reticulum (ER) protein (Herp) is an ER stress-inducible key regulatory component of ER-associated degradation (ERAD) that has been implicated in insulin hypersecretion in diabetic mouse models. Herp expression is tightly regulated. Additionally, Herp is a highly labi...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-05, Vol.473 (4), p.1276-1280
Hauptverfasser:	Maeda, Tomoji, Tanabe-Fujimura, Chiaki, Fujita, Yu, Abe, Chihiro, Nanakida, Yoshino, Zou, Kun, Liu, Junjun, Liu, Shuyu, Nakajima, Toshihiro, Komano, Hiroto
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BENZOQUINONES Binding Sites BIOLOGICAL STRESS Degradation ENDOPLASMIC RETICULUM HEK293 Cells HOMOCYSTEINE Homocysteine-induced endoplasmic reticulum protein Humans INSULIN LIGASES LYSINE Membrane Proteins - metabolism MICE NAD NAD(P)H Dehydrogenase (Quinone) - metabolism NAD(P)H quinone oxidoreductase 1 OXIDOREDUCTASES Proteasome Proteasome Endopeptidase Complex - metabolism Protein Binding Structure-Activity Relationship
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