Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway

Aberrant activation of Notch signaling frequently occurs in liver cancer, and is associated with liver malignancies. However, the mechanisms regulating pathologic Notch activation in hepatocellular carcinoma (HCC) remain unclear. Protein O-fucosyltransferase 1 (Pofut1) catalyzes the addition of O-li...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2016-04, Vol.473 (2), p.503-510
Hauptverfasser:	Ma, Lijie, Dong, Pingping, Liu, Longzi, Gao, Qiang, Duan, Meng, Zhang, Si, Chen, She, Xue, Ruyi, Wang, Xiaoying
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ALANINES AMINOTRANSFERASES ANIMAL TISSUES ANTIBODIES Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Movement CELL PROLIFERATION Female Fucosyltransferases - genetics Fucosyltransferases - metabolism Gene Expression Regulation, Neoplastic GROWTH FACTORS HAMSTERS HCC HEPATITIS HEPATOMAS HEXOSES Humans IN VITRO LIGANDS LIVER Liver - metabolism Liver - pathology Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male METASTASES Middle Aged Migration Notch OVARIES PHOSPHOTRANSFERASES POLYMERASE CHAIN REACTION Proliferation Protein O-fucosyltransferase 1 RECEPTORS Receptors, Notch - metabolism SERINE Signal Transduction THERAPY THREONINE Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!