Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation

The transferrin receptor (TfR1) is upregulated in malignant cells and its expression is associated with cancer progression. Because of its pre-eminent role in cell proliferation, TfR1 has been an important target for the development of cancer therapy. Although TfR1 is highly expressed in pancreatic...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-03, Vol.471 (3), p.373-379
Hauptverfasser:	Jeong, Seung Min, Hwang, Sunsook, Seong, Rho Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES adenocarcinoma Antigens, CD - metabolism CARCINOMAS Cell Line, Tumor CELL PROLIFERATION Cell Survival Humans IRON MITOCHONDRIA Mitochondria - metabolism Mitochondrial respiration OXIDATION oxidative phosphorylation Oxidative Stress Oxygen - metabolism PANCREAS pancreatic neoplasms Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology PDAC PHOSPHORYLATION PLANT GROWTH Reactive Oxygen Species - metabolism RECEPTORS Receptors, Transferrin - metabolism RESPIRATION ROS SENSITIVITY therapeutics THERAPY TRANSFERRIN Transferrin receptor
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