Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor

Receptor activity-modifying protein 2 (RAMP2) enables the calcitonin receptor-like receptor (CLR, a family B GPCR) to form the type 1 adrenomedullin receptor (AM1 receptor). Here, we investigated the effects of the five non-visual GPCR kinases (GRKs 2 through 6) on the cell surface expression of the...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-02, Vol.470 (4), p.894-899
Hauptverfasser:	Kuwasako, Kenji, Sekiguchi, Toshio, Nagata, Sayaka, Jiang, Danfeng, Hayashi, Hidetaka, Murakami, Manabu, Hattori, Yuichi, Kitamura, Kazuo, Kato, Johji
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Adrenomedullin AMP CALCITONIN Calcitonin receptor-like receptor Cell Membrane - metabolism Down-Regulation - physiology G-Protein-Coupled Receptor Kinase 4 - metabolism G-Protein-Coupled Receptor Kinase 5 - metabolism GTP-ASES HEK293 Cells Humans INHIBITION IODINE 125 MUTANTS MUTATIONS PH VALUE PHOSPHOTRANSFERASES Receptor activity-modifying protein 2 Receptor mutations Receptor trafficking RECEPTORS Receptors, Adrenomedullin - metabolism Receptors, G-Protein-Coupled - metabolism Signal transduction Signal Transduction - physiology SIGNALS STIMULATION SYMPATHOMIMETICS
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