Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration

Spinal and bulbar muscular atrophy (SBMA) is an inherited motor neuron disease caused by the expansion of a polyglutamine (polyQ)-encoding tract within the androgen receptor (AR) gene. The pathologic features of SBMA are motor neuron loss in the spinal cord and brainstem and diffuse nuclear accumula...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-12, Vol.468 (4), p.677-683
Hauptverfasser:	Ding, Ying, Adachi, Hiroaki, Katsuno, Masahisa, Huang, Zhe, Jiang, Yue-Mei, Kondo, Naohide, Iida, Madoka, Tohnai, Genki, Nakatsuji, Hideaki, Funakoshi, Hiroshi, Nakamura, Toshikazu, Sobue, Gen
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Akt Androgen receptor ANDROGENS Animals ATROPHY CASTRATION Castration - methods Combination therapy Combined Modality Therapy - methods Disease Models, Animal GROWTH FACTORS Hepatocyte growth factor Hepatocyte Growth Factor - metabolism LIVER CELLS Male Mice Mice, Inbred C57BL Mice, Transgenic Muscular Disorders, Atrophic - metabolism Muscular Disorders, Atrophic - therapy MUTANTS NERVE CELLS PHENOTYPE PHOSPHORYLATION POLYPEPTIDES RECEPTORS Spinal and bulbar muscular atrophy SPINAL CORD THERAPY TRANSGENIC MICE Treatment Outcome Up-Regulation
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