Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure

One limitation in using human pluripotent stem cell derived cardiomyocytes (hPSC-CMs) for disease modeling and cardiac safety pharmacology is their immature functional phenotype compared with adult cardiomyocytes. Here, we report that treatment of human embryonic stem cell derived cardiomyocytes (hE...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-11, Vol.467 (4), p.998-1005
Hauptverfasser:	Kosmidis, Georgios, Bellin, Milena, Ribeiro, Marcelo C., van Meer, Berend, Ward-van Oostwaard, Dorien, Passier, Robert, Tertoolen, Leon G.J., Mummery, Christine L., Casini, Simona
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES CALCIUM Calcium - metabolism Calcium handling CALCIUM IONS Cardiomyocytes CARDIOVASCULAR DISEASES Cell Line DEXAMETHASONE Dexamethasone - metabolism Dexamethasone - pharmacology ELECTROPHYSIOLOGY Embryonic Stem Cells - cytology Embryonic Stem Cells - drug effects Embryonic Stem Cells - metabolism Glucocorticoids Homeodomain Proteins - metabolism Human embryonic stem cells Humans Myocytes, Cardiac - cytology Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism PHARMACOLOGY PHENOTYPE Sarcoplasmic Reticulum Calcium-Transporting ATPases - metabolism Signal Transduction STEM CELLS
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