Delocalized Claudin-1 promotes metastasis of human osteosarcoma cells

Tight junction proteins (TJPs) including Claudins, Occludin and tight junction associated protein Zonula occludens-1 (ZO-1), are the most apical component of junctional complex that mediates cell–cell adhesion in epithelial and endothelial cells. In human malignancies, TJPs are often deregulated and...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-10, Vol.466 (3), p.356-361
Hauptverfasser:	Jian, Yuekui, Chen, Changqiong, Li, Bo, Tian, Xiaobin
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Cell Line Cell Line, Tumor Cell Nucleus - metabolism Cell Transformation, Neoplastic Claudin-1 - metabolism Claudin1 CONNECTIVE TISSUE CELLS CONNECTORS Cyclic AMP-Dependent Protein Kinases - metabolism Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Silencing Humans INHIBITION METASTASES Metastasis Neoplasm Invasiveness Neoplasm Metastasis Osteosarcoma Osteosarcoma - metabolism OSTEOSARCOMAS PHOSPHORYLATION Protein kinase C Protein Kinase C - metabolism PROTEINS TUMOR CELLS
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