Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity

Depleted uranium (DU) has been widely used in both civilian and military activities, and the kidney is the main target organ of DU during acute high-dose exposures. In this study, the nephrotoxicity caused by DU in metallothionein-1/2-null mice (MT−/−) and corresponding wild-type (MT+/+) mice was in...

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Veröffentlicht in:	Toxicology and applied pharmacology 2015-09, Vol.287 (3), p.306-315
Hauptverfasser:	Hao, Yuhui, Huang, Jiawei, Gu, Ying, Liu, Cong, Li, Hong, Liu, Jing, Ren, Jiong, Yang, Zhangyou, Peng, Shuangqing, Wang, Weidong, Li, Rong
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Antioxidants - metabolism APOPTOSIS Apoptosis - drug effects Apoptosis Regulatory Proteins - metabolism Biomarkers - blood BLOOD Blood Urea Nitrogen CATALASE Creatinine - blood DAMAGE DEPLETED URANIUM Disease Models, Animal HEMATOXYLIN INTRAPERITONEAL INJECTION Kidney - metabolism Kidney - pathology Kidney Diseases - chemically induced Kidney Diseases - genetics Kidney Diseases - metabolism Kidney Diseases - pathology KIDNEYS Male METALLOTHIONEIN Metallothionein - deficiency Metallothionein - genetics MICE Mice, Knockout Nephrotoxicity OXIDATION Oxidative stress Oxidative Stress - drug effects PYROCATECHOL Reactive Oxygen Species - metabolism SODIUM PHOSPHATES Sodium-glucose cotransporter Sodium-Glucose Transport Proteins - drug effects Sodium-Glucose Transport Proteins - metabolism STRESSES SUPEROXIDE DISMUTASE Time Factors Uranyl Nitrate
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