Coordinated induction of GST and MRP2 by cAMP in Caco-2 cells: Role of protein kinase A signaling pathway and toxicological relevance

The cAMP pathway is a universal signaling pathway regulating many cellular processes including metabolic routes, growth and differentiation. However, its effects on xenobiotic biotransformation and transport systems are poorly characterized. The effect of cAMP on expression and activity of GST and M...

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Veröffentlicht in:	Toxicology and applied pharmacology 2015-09, Vol.287 (2), p.178-190
Hauptverfasser:	Arana, Maite Rocío, Tocchetti, Guillermo Nicolás, Domizi, Pablo, Arias, Agostina, Rigalli, Juan Pablo, Ruiz, María Laura, Luquita, Marcelo Gabriel, Banchio, Claudia, Mottino, Aldo Domingo, Villanueva, Silvina Stella Maris
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AMP AP-1 Caco-2 Cells cAMP Colforsin - pharmacology CREB-Binding Protein - metabolism Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism DETOXIFICATION Dinitrochlorobenzene - pharmacology Dose-Response Relationship, Drug EPITHELIUM Glutathione Transferase - biosynthesis GST Humans INCUBATION INJURIES INTERACTIONS Intestine INTESTINES MRP2 Multidrug Resistance-Associated Proteins - biosynthesis PHOSPHORYLATION PKA PLANT GROWTH PROMOTERS Real-Time Polymerase Chain Reaction Signal Transduction SIGNALS SUBSTRATES Transcription Factor AP-1 - metabolism TRANSCRIPTION FACTORS XENOBIOTICS
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