Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma

Dopamine (DA), a monoamine catecholamine neurotransmitter with antiangiogenic activity, stabilizes tumor vessels in colon, prostate and ovarian cancers, thus increases chemotherapeutic efficacy. Here, in the rat C6 glioma models, we investigated the vascular normalization effects of DA and its mecha...

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Veröffentlicht in:	Toxicology and applied pharmacology 2015-07, Vol.286 (2), p.112-123
Hauptverfasser:	Qin, Tian, Wang, Chenlong, Chen, Xuewei, Duan, Chenfan, Zhang, Xiaoyan, Zhang, Jing, Chai, Hongyan, Tang, Tian, Chen, Honglei, Yue, Jiang, Li, Ying, Yang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Angiogenesis Inhibitors - pharmacology ANIMAL TISSUES Animals ANOXIA Antineoplastic Agents, Alkylating - pharmacology ARGINASE CATECHOLAMINES Cell Movement - drug effects Dacarbazine - analogs & derivatives Dacarbazine - pharmacology DOPAMINE Dopamine - pharmacology Gene Expression - drug effects Glioma Glioma - pathology GLIOMAS Growth GROWTH FACTORS INDIUM OXIDES INHIBITION LARGE INTESTINE Macrophage polarization MACROPHAGES Macrophages - drug effects Male MICE OVARIES PHENOTYPE PROSTATE RADIOPROTECTIVE SUBSTANCES RATS Rats, Wistar RECEPTORS Receptors, Dopamine D2 - drug effects SURVIVAL TIME Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular normalization VEGF/VEGFR2 signaling
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