In vitro biotransformation of tris(2-butoxyethyl) phosphate (TBOEP) in human liver and serum

Tris(2-butoxyethyl) phosphate (TBOEP) is a plasticizer present in indoor dust, reaching levels of several micrograms per gram. Such levels could lead to significant daily exposure of adults and children. Currently, no toxicokinetic data are available to estimate TBOEP clearance in humans after uptak...

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Veröffentlicht in:	Toxicology and applied pharmacology 2015-04, Vol.284 (2), p.246-253
Hauptverfasser:	Van den Eede, Nele, Erratico, Claudio, Exarchou, Vassiliki, Maho, Walid, Neels, Hugo, Covaci, Adrian
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES BIOLOGICAL PATHWAYS Biotransformation Chromatography, Liquid - methods CLEARANCE DATA Dust - analysis DUSTS Environmental Monitoring - methods ENZYMES Female Human liver microsomes HUMAN POPULATIONS Humans IN VITRO In vitro clearance In Vitro Techniques ISOMERS Kinetics LIQUID COLUMN CHROMATOGRAPHY LIVER Liver - metabolism Magnetic Resonance Imaging - methods Male MASS SPECTROSCOPY METABOLISM METABOLITES MICROSOMES Microsomes, Liver - metabolism NUCLEAR MAGNETIC RESONANCE Organophosphorus Compounds - blood Organophosphorus Compounds - pharmacokinetics PHOSPHATES PLASTICIZERS Plasticizers - pharmacokinetics RISK ASSESSMENT Serum Tandem Mass Spectrometry - methods TBOEP Tris(2-butoxyethyl) phosphate UPTAKE
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