Dimethyl sulfoxide inhibits spontaneous diabetes and autoimmune recurrence in non-obese diabetic mice by inducing differentiation of regulatory T cells

Type 1 diabetes mellitus (T1D) is caused by the destruction of insulin-producing β cells in pancreatic islets by autoimmune T cells. Islet transplantation has been established as an effective therapeutic strategy for T1D. However, the survival of islet grafts can be disrupted by recurrent autoimmuni...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Toxicology and applied pharmacology 2015-01, Vol.282 (2), p.207-214
Hauptverfasser:	Lin, Gu-Jiun, Sytwu, Huey-Kang, Yu, Jyh-Cherng, Chen, Yuan-Wu, Kuo, Yu-Liang, Yu, Chiao-Chi, Chang, Hao-Ming, Chan, De-Chuan, Huang, Shing-Hwa
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Autoimmune Diseases - prevention & control Autoimmune recurrence Blood Glucose - metabolism Body Weight - drug effects CELL DIFFERENTIATION Cell Differentiation - drug effects DIABETES MELLITUS Diabetes Mellitus - prevention & control Dimethyl sulfoxide Dimethyl Sulfoxide - pharmacology DMSO GRAFTS HUMAN POPULATIONS IN VITRO IN VIVO INFLAMMATION INHIBITION INSULIN Insulin - metabolism INTERFERON Islet transplantation Islets of Langerhans Transplantation MICE Mice, Inbred NOD Mice, SCID NOD mice PANCREAS Regulatory T cell SIGNALS SOLVENTS T-Lymphocytes, Regulatory - drug effects Type 1 diabetes
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!