Preoperative Single-Fraction Partial Breast Radiation Therapy: A Novel Phase 1, Dose-Escalation Protocol With Radiation Response Biomarkers

Purpose Women with biologically favorable early-stage breast cancer are increasingly treated with accelerated partial breast radiation (PBI). However, treatment-related morbidities have been linked to the large postoperative treatment volumes required for external beam PBI. Relative to external beam...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-07, Vol.92 (4), p.846-855
Hauptverfasser:	Horton, Janet K., MD, Blitzblau, Rachel C., MD, PhD, Yoo, Sua, PhD, Geradts, Joseph, MD, Chang, Zheng, PhD, Baker, Jay A., MD, Georgiade, Gregory S., MD, Chen, Wei, PhD, Siamakpour-Reihani, Sharareh, PhD, Wang, Chunhao, BS, Broadwater, Gloria, MS, Groth, Jeff, BA, Palta, Manisha, MD, Dewhirst, Mark, DVM, PhD, Barry, William T., PhD, Duffy, Eileen A., RGN, Chi, Jen-Tsan A., MD, PhD, Hwang, E. Shelley, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged APOPTOSIS BIOLOGICAL MARKERS BIOMEDICAL RADIOGRAPHY Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - radiotherapy Breast Neoplasms - surgery Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Ductal, Breast - radiotherapy Carcinoma, Ductal, Breast - surgery Carcinoma, Intraductal, Noninfiltrating - genetics Carcinoma, Intraductal, Noninfiltrating - pathology Carcinoma, Intraductal, Noninfiltrating - radiotherapy Carcinoma, Intraductal, Noninfiltrating - surgery CARCINOMAS CLINICAL TRIALS DISEASE INCIDENCE ELDERLY PEOPLE ESTROGENS Feasibility Studies Female Gene Expression Genetic Markers Hematology, Oncology and Palliative Medicine Humans MAMMARY GLANDS Mastectomy, Segmental Middle Aged PATIENTS Preoperative Care PROGESTERONE RADIATION DOSES Radiation Injuries - pathology Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Radiotherapy, Intensity-Modulated - methods RECEPTORS WOMEN
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