Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients
Purpose Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-i...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2015-07, Vol.92 (3), p.613-618 |
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| container_title | International journal of radiation oncology, biology, physics |
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| creator | Ghorbanzadeh-Moghaddam, Amir, MD Gholamrezaei, Ali, MD Hemati, Simin, MD |
| description | Purpose Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of |
| doi_str_mv | 10.1016/j.ijrobp.2015.02.011 |
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| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22462355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0360301615001789</els_id><sourcerecordid>1688003745</sourcerecordid><originalsourceid>FETCH-LOGICAL-c515t-a82cb96a2878a490fc727f43e276168907237a0dc9dd720ff39869b0967c84b33</originalsourceid><addsrcrecordid>eNqFkktv1DAUhS0EokPhHyBkiQ2bBD-S2NkgVVNoR6pERXntLMe50Thk7KntVJp_j6MUFmxYeeHvnHt17kHoNSUlJbR5P5Z2DL47lozQuiSsJJQ-QRsqRVvwuv75FG0Ib0jBM3yGXsQ4EpIRUT1HZ6yWLZFVtUHDd5v0wTp8iS9hsMaCMye8i_giRm-sTtDjHzbtcdoDvoMHCDadsB_wF93nX-tdsXP9bDJ2G7xJNtmIs91WOwMB32YEXIov0bNBTxFePb7n6Nunj1-318XN56vd9uKmMDWtU6ElM13baCaF1FVLBiOYGCoOTDS0yTsLxoUmvWn7XjAyDLyVTduRthFGVh3n5-jt6utjsioam8DsjXcOTFKMVQ3L0WTq3Uodg7-fISZ1sNHANGkHfo4qj5KEcFEtaLWiJvgYAwzqGOxBh5OiRC13UKNa76CWOyjCVA45y948Tpi7A_R_RX-Cz8CHFYCcxoOFsCybs4fehmXX3tv_TfjXwEzWWaOnX3CCOPo5uJy0oipmgbpburBUgda5BUK2_Df9n65V</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1688003745</pqid></control><display><type>article</type><title>Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Ghorbanzadeh-Moghaddam, Amir, MD ; Gholamrezaei, Ali, MD ; Hemati, Simin, MD</creator><creatorcontrib>Ghorbanzadeh-Moghaddam, Amir, MD ; Gholamrezaei, Ali, MD ; Hemati, Simin, MD</creatorcontrib><description>Purpose Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of <35 nmol/L and <40 nmol/L in male and female patients, respectively, based on available normative data. Acute proctitis was assessed after 5 weeks of radiation therapy (total received radiation dose of 50 Gy) and graded from 0 to 4 using Radiation Therapy Oncology Group (RTOG) criteria. Results Ninety-eight patients (57.1% male) with a mean age of 62.8 ± 9.1 years were studied. Vitamin D deficiency was found in 57 patients (58.1%). Symptoms of acute proctitis occurred in 72 patients (73.4%) after radiation therapy. RTOG grade was significantly higher in patients with vitamin D deficiency than in normal cases (median [interquartile range] of 2 [0.5-3] vs 1 [0-2], P =.037). Vitamin D deficiency was associated with RTOG grade of ≥2, independent of possible confounding factors; odds ratio (95% confidence interval) = 3.07 (1.27-7.50), P =.013. Conclusions Vitamin D deficiency is associated with increased severity of radiation-induced acute proctitis. Investigating the underlying mechanisms of this association and evaluating the effectiveness of vitamin D therapy in preventing radiation-induced acute proctitis is warranted.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2015.02.011</identifier><identifier>PMID: 25890844</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute Disease ; Aged ; ANIMAL TISSUES ; Female ; Genital Neoplasms, Female - blood ; Genital Neoplasms, Female - radiotherapy ; Hematology, Oncology and Palliative Medicine ; Humans ; INFLAMMATION ; INJURIES ; Intestinal Mucosa - radiation effects ; Male ; Middle Aged ; NEOPLASMS ; PATIENTS ; PROCTITIS ; Proctitis - etiology ; Prospective Studies ; Prostatic Neoplasms - blood ; Prostatic Neoplasms - radiotherapy ; RADIATION DOSES ; Radiation Injuries - complications ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Urinary Bladder Neoplasms - blood ; Urinary Bladder Neoplasms - radiotherapy ; VITAMIN D ; Vitamin D - blood ; Vitamin D Deficiency - complications</subject><ispartof>International journal of radiation oncology, biology, physics, 2015-07, Vol.92 (3), p.613-618</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c515t-a82cb96a2878a490fc727f43e276168907237a0dc9dd720ff39869b0967c84b33</citedby><cites>FETCH-LOGICAL-c515t-a82cb96a2878a490fc727f43e276168907237a0dc9dd720ff39869b0967c84b33</cites><orcidid>0000-0001-8674-450X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijrobp.2015.02.011$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,781,785,886,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25890844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22462355$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Ghorbanzadeh-Moghaddam, Amir, MD</creatorcontrib><creatorcontrib>Gholamrezaei, Ali, MD</creatorcontrib><creatorcontrib>Hemati, Simin, MD</creatorcontrib><title>Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of <35 nmol/L and <40 nmol/L in male and female patients, respectively, based on available normative data. Acute proctitis was assessed after 5 weeks of radiation therapy (total received radiation dose of 50 Gy) and graded from 0 to 4 using Radiation Therapy Oncology Group (RTOG) criteria. Results Ninety-eight patients (57.1% male) with a mean age of 62.8 ± 9.1 years were studied. Vitamin D deficiency was found in 57 patients (58.1%). Symptoms of acute proctitis occurred in 72 patients (73.4%) after radiation therapy. RTOG grade was significantly higher in patients with vitamin D deficiency than in normal cases (median [interquartile range] of 2 [0.5-3] vs 1 [0-2], P =.037). Vitamin D deficiency was associated with RTOG grade of ≥2, independent of possible confounding factors; odds ratio (95% confidence interval) = 3.07 (1.27-7.50), P =.013. Conclusions Vitamin D deficiency is associated with increased severity of radiation-induced acute proctitis. Investigating the underlying mechanisms of this association and evaluating the effectiveness of vitamin D therapy in preventing radiation-induced acute proctitis is warranted.</description><subject>Acute Disease</subject><subject>Aged</subject><subject>ANIMAL TISSUES</subject><subject>Female</subject><subject>Genital Neoplasms, Female - blood</subject><subject>Genital Neoplasms, Female - radiotherapy</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>INFLAMMATION</subject><subject>INJURIES</subject><subject>Intestinal Mucosa - radiation effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>NEOPLASMS</subject><subject>PATIENTS</subject><subject>PROCTITIS</subject><subject>Proctitis - etiology</subject><subject>Prospective Studies</subject><subject>Prostatic Neoplasms - blood</subject><subject>Prostatic Neoplasms - radiotherapy</subject><subject>RADIATION DOSES</subject><subject>Radiation Injuries - complications</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Urinary Bladder Neoplasms - blood</subject><subject>Urinary Bladder Neoplasms - radiotherapy</subject><subject>VITAMIN D</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - complications</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAUhS0EokPhHyBkiQ2bBD-S2NkgVVNoR6pERXntLMe50Thk7KntVJp_j6MUFmxYeeHvnHt17kHoNSUlJbR5P5Z2DL47lozQuiSsJJQ-QRsqRVvwuv75FG0Ib0jBM3yGXsQ4EpIRUT1HZ6yWLZFVtUHDd5v0wTp8iS9hsMaCMye8i_giRm-sTtDjHzbtcdoDvoMHCDadsB_wF93nX-tdsXP9bDJ2G7xJNtmIs91WOwMB32YEXIov0bNBTxFePb7n6Nunj1-318XN56vd9uKmMDWtU6ElM13baCaF1FVLBiOYGCoOTDS0yTsLxoUmvWn7XjAyDLyVTduRthFGVh3n5-jt6utjsioam8DsjXcOTFKMVQ3L0WTq3Uodg7-fISZ1sNHANGkHfo4qj5KEcFEtaLWiJvgYAwzqGOxBh5OiRC13UKNa76CWOyjCVA45y948Tpi7A_R_RX-Cz8CHFYCcxoOFsCybs4fehmXX3tv_TfjXwEzWWaOnX3CCOPo5uJy0oipmgbpburBUgda5BUK2_Df9n65V</recordid><startdate>20150701</startdate><enddate>20150701</enddate><creator>Ghorbanzadeh-Moghaddam, Amir, MD</creator><creator>Gholamrezaei, Ali, MD</creator><creator>Hemati, Simin, MD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0001-8674-450X</orcidid></search><sort><creationdate>20150701</creationdate><title>Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients</title><author>Ghorbanzadeh-Moghaddam, Amir, MD ; Gholamrezaei, Ali, MD ; Hemati, Simin, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c515t-a82cb96a2878a490fc727f43e276168907237a0dc9dd720ff39869b0967c84b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Acute Disease</topic><topic>Aged</topic><topic>ANIMAL TISSUES</topic><topic>Female</topic><topic>Genital Neoplasms, Female - blood</topic><topic>Genital Neoplasms, Female - radiotherapy</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>INFLAMMATION</topic><topic>INJURIES</topic><topic>Intestinal Mucosa - radiation effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>NEOPLASMS</topic><topic>PATIENTS</topic><topic>PROCTITIS</topic><topic>Proctitis - etiology</topic><topic>Prospective Studies</topic><topic>Prostatic Neoplasms - blood</topic><topic>Prostatic Neoplasms - radiotherapy</topic><topic>RADIATION DOSES</topic><topic>Radiation Injuries - complications</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Urinary Bladder Neoplasms - blood</topic><topic>Urinary Bladder Neoplasms - radiotherapy</topic><topic>VITAMIN D</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ghorbanzadeh-Moghaddam, Amir, MD</creatorcontrib><creatorcontrib>Gholamrezaei, Ali, MD</creatorcontrib><creatorcontrib>Hemati, Simin, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ghorbanzadeh-Moghaddam, Amir, MD</au><au>Gholamrezaei, Ali, MD</au><au>Hemati, Simin, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2015-07-01</date><risdate>2015</risdate><volume>92</volume><issue>3</issue><spage>613</spage><epage>618</epage><pages>613-618</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of <35 nmol/L and <40 nmol/L in male and female patients, respectively, based on available normative data. Acute proctitis was assessed after 5 weeks of radiation therapy (total received radiation dose of 50 Gy) and graded from 0 to 4 using Radiation Therapy Oncology Group (RTOG) criteria. Results Ninety-eight patients (57.1% male) with a mean age of 62.8 ± 9.1 years were studied. Vitamin D deficiency was found in 57 patients (58.1%). Symptoms of acute proctitis occurred in 72 patients (73.4%) after radiation therapy. RTOG grade was significantly higher in patients with vitamin D deficiency than in normal cases (median [interquartile range] of 2 [0.5-3] vs 1 [0-2], P =.037). Vitamin D deficiency was associated with RTOG grade of ≥2, independent of possible confounding factors; odds ratio (95% confidence interval) = 3.07 (1.27-7.50), P =.013. Conclusions Vitamin D deficiency is associated with increased severity of radiation-induced acute proctitis. Investigating the underlying mechanisms of this association and evaluating the effectiveness of vitamin D therapy in preventing radiation-induced acute proctitis is warranted.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25890844</pmid><doi>10.1016/j.ijrobp.2015.02.011</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8674-450X</orcidid></addata></record> |
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| subjects | Acute Disease Aged ANIMAL TISSUES Female Genital Neoplasms, Female - blood Genital Neoplasms, Female - radiotherapy Hematology, Oncology and Palliative Medicine Humans INFLAMMATION INJURIES Intestinal Mucosa - radiation effects Male Middle Aged NEOPLASMS PATIENTS PROCTITIS Proctitis - etiology Prospective Studies Prostatic Neoplasms - blood Prostatic Neoplasms - radiotherapy RADIATION DOSES Radiation Injuries - complications Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Urinary Bladder Neoplasms - blood Urinary Bladder Neoplasms - radiotherapy VITAMIN D Vitamin D - blood Vitamin D Deficiency - complications |
| title | Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients |
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