Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells

The poor outcome of osteosarcoma (OS), particularly in patients with metastatic disease and a five-year survival rate of only 20%, asks for more effective therapeutic strategies targeting malignancy-promoting mechanisms. Dysregulation of C-MET, its ligand hepatocyte growth factor (HGF) and the fusio...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-09, Vol.464 (4), p.1222-1227
Hauptverfasser:	Husmann, Knut, Ducommun, Pascal, Sabile, Adam A., Pedersen, Else-Marie, Born, Walter, Fuchs, Bruno
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES C-MET Cell Line, Tumor COMPARATIVE EVALUATIONS Down-Regulation - drug effects Gene Expression Regulation, Neoplastic - drug effects GROWTH FACTORS Hepatocyte Growth Factor - pharmacology HUMAN POPULATIONS Humans LIGANDS MESSENGER-RNA METASTASES ONCOGENES Osteosarcoma Osteosarcoma - metabolism Osteosarcoma - pathology Osteosarcoma - secondary OSTEOSARCOMAS PATIENTS PHOSPHORYLATION Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction SIGNALS TPR-MET
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