Acidic environment augments FcεRI-mediated production of IL-6 and IL-13 in mast cells

Although blood pH is maintained in a narrow range of around pH 7.4 in living organisms, inflammatory loci are characterized by acidic conditions. Mast cells tend to reside close to the surface of the body in areas such as the mucosa and skin where they may be exposed to exogenous acids, and they pla...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-08, Vol.464 (3), p.949-955
Hauptverfasser:	Kamide, Yosuke, Ishizuka, Tamotsu, Tobo, Masayuki, Tsurumaki, Hiroaki, Aoki, Haruka, Mogi, Chihiro, Nakakura, Takashi, Yatomi, Masakiyo, Ono, Akihiro, Koga, Yasuhiko, Sato, Koichi, Hisada, Takeshi, Dobashi, Kunio, Yamada, Masanobu, Okajima, Fumikazu
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACIDIFICATION ALBUMINS Animals ANTIGENS BLOOD SERUM BONE MARROW Cell Movement Cells, Cultured DINITROPHENOL Dinitrophenols - pharmacology ENVIRONMENT Extracellular acidification Hydrogen-Ion Concentration IL-13 IL-6 Immunoglobulin E - immunology Immunoglobulin E - metabolism INFLAMMATION INHIBITION Interleukin Interleukin-13 - metabolism Interleukin-6 - metabolism MAST CELLS Mast Cells - chemistry Mast Cells - drug effects Mast Cells - immunology Mast Cells - metabolism MICE Mice, Inbred C57BL Mice, Mutant Strains MUCOUS MEMBRANES p38 MAPK p38 Mitogen-Activated Protein Kinases - metabolism PH VALUE Proto-Oncogene Proteins c-akt - metabolism PROTONS Receptors, G-Protein-Coupled - genetics Receptors, G-Protein-Coupled - metabolism Receptors, IgE - metabolism Serum Albumin - pharmacology SKIN SURFACES
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