LRIG1, a 3p tumor suppressor, represses EGFR signaling and is a novel epigenetic silenced gene in colorectal cancer

Downregulation of LRIG1 was found in many types of cancer. However, data concerning the possible mechanism of LRIG1 reduction in cancers were not reported yet. To analyze the regulation and function of LRIG1 in colorectal cancer (CRC), 6 cell lines, 46 paired tissues from primary CRC cases were empl...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-08, Vol.464 (2), p.519-525
Hauptverfasser:	Kou, Changhua, Zhou, Tian, Han, Xilin, Zhuang, Huijie, Qian, Haixin
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ANIMAL TISSUES APOPTOSIS BIOLOGICAL RECOVERY Cell Line, Tumor CELL PROLIFERATION Chromosomes, Human, Pair 3 COLONY FORMATION Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology COMPARATIVE EVALUATIONS DNA Methylation EGFR signaling Epigenesis, Genetic GENES Humans IN VITRO IN VIVO LRIG1 Membrane Glycoproteins - genetics Membrane Glycoproteins - physiology MESSENGER-RNA METHYLATION NEOPLASMS PLANT GROWTH Proliferation Promoter Regions, Genetic PROMOTERS PROTEINS Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - metabolism Signal Transduction - physiology SIGNALS
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