Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin

Girdin is an actin-binding protein that has multiple functions in postnatal neural development and cancer progression. We previously showed that Girdin is a regulator of migration for neuroblasts born from neural stem cells in the subventricular zone (SVZ) and the dentate gyrus of the hippocampus in...

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Veröffentlicht in:Biochemical and biophysical research communications 2015-08, Vol.463 (4), p.999-1005
Hauptverfasser: Muramatsu, Aya, Enomoto, Atsushi, Kato, Takuya, Weng, Liang, Kuroda, Keisuke, Asai, Naoya, Asai, Masato, Mii, Shinji, Takahashi, Masahide
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container_end_page 1005
container_issue 4
container_start_page 999
container_title Biochemical and biophysical research communications
container_volume 463
creator Muramatsu, Aya
Enomoto, Atsushi
Kato, Takuya
Weng, Liang
Kuroda, Keisuke
Asai, Naoya
Asai, Masato
Mii, Shinji
Takahashi, Masahide
description Girdin is an actin-binding protein that has multiple functions in postnatal neural development and cancer progression. We previously showed that Girdin is a regulator of migration for neuroblasts born from neural stem cells in the subventricular zone (SVZ) and the dentate gyrus of the hippocampus in the postnatal brain. Despite a growing list of Girdin-interacting proteins, the mechanism of Girdin-mediated migration has not been fully elucidated. Girdin interacts with Disrupted-In-Schizophrenia 1 and partitioning-defective 3, both of which have been shown to interact with the kinesin microtubule motor proteins. Based on this, we have identified that Girdin also interacts with kinesin-1, a member of neuronal kinesin proteins. Although a direct interaction of Girdin and kinesin-1 has not been determined, it is of interest to find that Girdin loss-of-function mutant mice with the mutation of a basic amino acid residue-rich region (Basic mut mice) exhibit limited interaction with kinesin-1. Furthermore, expression of a kinesin-1 mutant with motor defects, leads to Girdin mislocalization. Finally, consistent with previous studies on the role of kinesin proteins in trafficking a cell–cell adhesion molecule N-cadherin, Basic mut mice showed an aberrant expression pattern of N-cadherin in migrating SVZ neuroblasts. These findings suggest a potential role of Girdin/kinesin-1 interaction in the regulation of neuroblast migration in the postnatal brain. •Girdin is a regulator of migration for neuroblasts in the postnatal brain.•Girdin interacts with kinesin-1, a member of neuronal kinesin proteins.•Girdin mutant mice showed an aberrant expression of N-cadherin in neuroblasts.
doi_str_mv 10.1016/j.bbrc.2015.06.049
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We previously showed that Girdin is a regulator of migration for neuroblasts born from neural stem cells in the subventricular zone (SVZ) and the dentate gyrus of the hippocampus in the postnatal brain. Despite a growing list of Girdin-interacting proteins, the mechanism of Girdin-mediated migration has not been fully elucidated. Girdin interacts with Disrupted-In-Schizophrenia 1 and partitioning-defective 3, both of which have been shown to interact with the kinesin microtubule motor proteins. Based on this, we have identified that Girdin also interacts with kinesin-1, a member of neuronal kinesin proteins. Although a direct interaction of Girdin and kinesin-1 has not been determined, it is of interest to find that Girdin loss-of-function mutant mice with the mutation of a basic amino acid residue-rich region (Basic mut mice) exhibit limited interaction with kinesin-1. Furthermore, expression of a kinesin-1 mutant with motor defects, leads to Girdin mislocalization. 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language eng
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source MEDLINE; Elsevier ScienceDirect Journals
subjects 60 APPLIED LIFE SCIENCES
ACTIN
ADHESION
AMINO ACIDS
Animals
Cadherins - metabolism
Collective migration
Girdin
HIPPOCAMPUS
Kinesin
Kinesin - metabolism
Kinesin - physiology
Lateral Ventricles - metabolism
MICE
Mice, Mutant Strains
Microfilament Proteins - metabolism
MICROTUBULES
MOLECULES
MOTORS
MUTANTS
MUTATIONS
N-cadherin
NEOPLASMS
OLFACTORY BULBS
PARTITION
Rostral migratory stream
STEM CELLS
Subcellular Fractions - metabolism
Vesicular Transport Proteins - metabolism
title Potential involvement of kinesin-1 in the regulation of subcellular localization of Girdin
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