NDR1 modulates the UV-induced DNA-damage checkpoint and nucleotide excision repair

Nucleotide excision repair (NER) is the sole mechanism of UV-induced DNA lesion repair in mammals. A single round of NER requires multiple components including seven core NER factors, xeroderma pigmentosum A–G (XPA–XPG), and many auxiliary effector proteins including ATR serine/threonine kinase. The...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-06, Vol.461 (3), p.543-548
Hauptverfasser:	Park, Jeong-Min, Choi, Ji Ye, Yi, Joo Mi, Chung, Jin Woong, Leem, Sun-Hee, Koh, Sang Seok, Kang, Tae-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ATR Cell Line, Tumor Cells, Cultured CHROMATIN CONGENITAL DISEASES CYTOPLASM DNA DNA Damage DNA DAMAGES DNA Repair DNA-Binding Proteins - metabolism EXCISION REPAIR Gene Silencing HEREDITARY DISEASES Humans IRRADIATION MAMMALS NDR1 NEOPLASMS Nucleotide excision repair NUCLEOTIDES Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - physiology PROTEINS PYRIMIDINE DIMERS RNA, Small Interfering SERINE SKIN DISEASES THREONINE Ultraviolet Rays XPA
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