SENP1 inhibition induces apoptosis and growth arrest of multiple myeloma cells through modulation of NF-κB signaling

SUMO/sentrin specific protease 1 (Senp1) is an important regulation protease in the protein sumoylation, which affects the cell cycle, proliferation and differentiation. The role of Senp1 mediated protein desumoylation in pathophysiological progression of multiple myeloma is unknown. In this study,...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-05, Vol.460 (2), p.409-415
Hauptverfasser:	Xu, Jun, Sun, Hui-Yan, Xiao, Feng-Jun, Wang, Hua, Yang, Yang, Wang, Lu, Gao, Chun-Ji, Guo, Zi-Kuan, Wu, Chu-Tse, Wang, Li-Sheng
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES APOPTOSIS CELL CYCLE Cell Division Cell Line, Tumor cell viability COLONY FORMATION Cysteine Endopeptidases Endopeptidases - genetics Endopeptidases - metabolism Gene Knockdown Techniques Gene Silencing HEK293 Cells Humans IL-6 INACTIVATION INHIBITION interleukin-6 MODULATION Multiple myeloma Multiple Myeloma - metabolism Multiple Myeloma - pathology myeloma NF-kappa B - metabolism NF-кB PHOSPHORYLATION PLANT GROWTH proteinases PROTEINS Senp1 Signal Transduction SIGNALS transcription factor NF-kappa B VIABILITY
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