Inhibitory effect of cucurbitacin B on imiquimod-induced skin inflammation

Psoriasis is a common skin disease, of which pathogenesis involves the increase of inflammatory reaction in epidermal cells. In an attempt to find therapeutics for psoriasis, we found that cucurbitacin B has an inhibitory potential on imiquimod-induced inflammation of keratinocytes. Cucurbitacin B s...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-04, Vol.459 (4), p.673-678
Hauptverfasser:	Li, Zheng Jun, Shin, Jung-Min, Choi, Dae-Kyoung, Lim, Seul Ki, Yoon, Tae-Jin, Lee, Young Ho, Sohn, Kyung-Cheol, Im, Myung, Lee, Young, Seo, Young-Joon, Kim, Chang Deok, Lee, Jeung-Hoon
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Aminoquinolines - pharmacology Base Sequence Cucurbitacin B DERMATITIS Dermatitis - drug therapy DNA Primers HUMAN POPULATIONS Humans Imiquimod In Vitro Techniques INFLAMMATION Keratinocytes LYMPHOKINES NF-κB PATHOGENESIS PLANT GROWTH PSORIASIS Real-Time Polymerase Chain Reaction SIGNALS SKIN STAT3 Triterpenes - pharmacology
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