10-oxo-12(Z)-octadecenoic acid, a linoleic acid metabolite produced by gut lactic acid bacteria, potently activates PPARγ and stimulates adipogenesis

Our previous study has shown that gut lactic acid bacteria generate various kinds of fatty acids from polyunsaturated fatty acids such as linoleic acid (LA). In this study, we investigated the effects of LA and LA-derived fatty acids on the activation of peroxisome proliferator-activated receptors (...

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Veröffentlicht in:	Biochemical and biophysical research communications 2015-04, Vol.459 (4), p.597-603
Hauptverfasser:	Goto, Tsuyoshi, Kim, Young-Il, Furuzono, Tomoya, Takahashi, Nobuyuki, Yamakuni, Kanae, Yang, Ha-Eun, Li, Yongjia, Ohue, Ryuji, Nomura, Wataru, Sugawara, Tatsuya, Yu, Rina, Kitamura, Nahoko, Park, Si-Bum, Kishino, Shigenobu, Ogawa, Jun, Kawada, Teruo
Format:	Artikel
Sprache:	eng
Schlagworte:	10-oxo-12(Z)-octadecenoic acid 60 APPLIED LIFE SCIENCES Adipocyte differentiation Adipogenesis - drug effects Animals BACTERIA Energy Metabolism Fatty acid GLUCOSE Gut lactic acid bacteria INSULIN LACTIC ACID Lactobacillus - metabolism LINOLEIC ACID Linoleic Acids - biosynthesis Linoleic Acids - pharmacology LIPASES LIPOPROTEINS LUCIFERASE METABOLIC DISEASES METABOLISM Mice NIH 3T3 Cells Obesity OCTADECANOIC ACID OLEIC ACID Polymerase Chain Reaction PPAR gamma - metabolism PPARγ RECEPTORS UPTAKE
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