Regulatory T Cells Promote β-Catenin–Mediated Epithelium-to-Mesenchyme Transition During Radiation-Induced Pulmonary Fibrosis

Purpose Radiation-induced pulmonary fibrosis results from thoracic radiation therapy and severely limits radiation therapy approaches. CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) as well as epithelium-to-mesenchyme transition (EMT) cells are involved in pulmonary fibrosis induced by multiple factor...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-10, Vol.93 (2), p.425-435
Hauptverfasser:	Xiong, Shanshan, PhD, Pan, Xiujie, MD, Xu, Long, PhD, Yang, Zhihua, Guo, Renfeng, PhD, Gu, Yongqing, PhD, Li, Ruoxi, Wang, Qianjun, Xiao, Fengjun, Du, Li, PhD, Zhou, Pingkun, PhD, Zhu, Maoxiang, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals ANTIBODIES beta Catenin - genetics beta Catenin - physiology CHEST Cobalt Radioisotopes - pharmacology Epithelial-Mesenchymal Transition - physiology EPITHELIUM Female FIBROSIS Flow Cytometry - methods Gene Knockdown Techniques Hematology, Oncology and Palliative Medicine Interleukin-2 Receptor alpha Subunit - immunology INTRAPERITONEAL INJECTION IRRADIATION LUNGS Lymphocyte Depletion - methods MICE Mice, Inbred C57BL Pulmonary Alveoli - pathology Pulmonary Alveoli - radiation effects Radiation Pneumonitis - etiology Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Random Allocation RNA SPLEEN T-Lymphocytes, Regulatory - cytology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - physiology
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