Impact of 1p/19q Codeletion and Histology on Outcomes of Anaplastic Gliomas Treated With Radiation Therapy and Temozolomide

Purpose Anaplastic gliomas represent a heterogeneous group of primary high-grade brain tumors, and the optimal postoperative treatment remains controversial. In this report, we present our institutional data on the clinical outcomes of radiation therapy (RT) plus temozolomide (RT + TMZ) for anaplast...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2015-02, Vol.91 (2), p.268-276
Hauptverfasser:	Speirs, Christina K., MD, PhD, Simpson, Joseph R., MD, PhD, Robinson, Clifford G., MD, DeWees, Todd A., PhD, Tran, David D., MD, PhD, Linette, Gerry, MD, Chicoine, Michael R., MD, Dacey, Ralph G., MD, Rich, Keith M., MD, Dowling, Joshua L., MD, Leuthardt, Eric C., MD, Zipfel, Gregory J., MD, Kim, Albert H., MD, PhD, Huang, Jiayi, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Agents, Alkylating - therapeutic use Antineoplastic Combined Chemotherapy Protocols - therapeutic use BRAIN Brain Neoplasms - genetics Brain Neoplasms - mortality Brain Neoplasms - pathology Brain Neoplasms - therapy Chemoradiotherapy Chromosome Deletion Chromosomes, Human, Pair 1 - genetics Chromosomes, Human, Pair 19 - genetics COMPARATIVE EVALUATIONS Dacarbazine - analogs & derivatives Dacarbazine - therapeutic use Female Gene Deletion Genetic Predisposition to Disease - epidemiology Genetic Predisposition to Disease - genetics Glioma - genetics Glioma - mortality Glioma - pathology Glioma - therapy GLIOMAS GY RANGE 10-100 Hematology, Oncology and Palliative Medicine HISTOLOGY Humans Male Middle Aged Missouri - epidemiology MULTIVARIATE ANALYSIS PATIENTS Prevalence RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy Dosage Retrospective Studies REVIEWS Risk Factors SURGERY Survival Rate Treatment Outcome Young Adult
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