Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy
Purpose We evaluated patient and treatment parameters correlated with development of temporal lobe radiation necrosis. Methods and Materials This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignanci...
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| description | Purpose We evaluated patient and treatment parameters correlated with development of temporal lobe radiation necrosis. Methods and Materials This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignancies between 2005 and 2012, who had at least 6 months of clinical and radiographic follow-up. The median radiation dose was 75.6 Gy (relative biological effectiveness [RBE]). Analyzed factors included gender, age, hypertension, diabetes, smoking status, use of chemotherapy, and the absolute dose:volume data for both the right and left temporal lobes, considered separately. A generalized estimating equation (GEE) regression analysis evaluated potential predictors of radiation necrosis, and the median effective concentration (EC50) model estimated dose–volume parameters associated with radiation necrosis. Results Median follow-up time was 31 months (range 6-96 months) and was 34 months in patients who were alive. The Kaplan-Meier estimate of overall survival at 3 years was 84.9%. The 3-year estimate of any grade temporal lobe radiation necrosis was 12.4%, and for grade 2 or higher radiation necrosis was 5.7%. On multivariate GEE, only dose–volume relationships were associated with the risk of radiation necrosis. In the EC50 model, all dose levels from 10 to 70 Gy (RBE) were highly correlated with radiation necrosis, with a 15% 3-year risk of any-grade temporal lobe radiation necrosis when the absolute volume of a temporal lobe receiving 60 Gy (RBE) (aV60) exceeded 5.5 cm3 , or aV70 > 1.7 cm3. Conclusions Dose–volume parameters are highly correlated with the risk of developing temporal lobe radiation necrosis. In this study the risk of radiation necrosis increased sharply when the temporal lobe aV60 exceeded 5.5 cm3 or aV70 > 1.7 cm3 . Treatment planning goals should include constraints on the volume of temporal lobes receiving higher dose. The EC50 model provides suggested dose–volume temporal lobe constraints for conventionally fractionated high-dose skull base radiation therapy. |
| doi_str_mv | 10.1016/j.ijrobp.2014.10.011 |
| format | Article |
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Methods and Materials This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignancies between 2005 and 2012, who had at least 6 months of clinical and radiographic follow-up. The median radiation dose was 75.6 Gy (relative biological effectiveness [RBE]). Analyzed factors included gender, age, hypertension, diabetes, smoking status, use of chemotherapy, and the absolute dose:volume data for both the right and left temporal lobes, considered separately. A generalized estimating equation (GEE) regression analysis evaluated potential predictors of radiation necrosis, and the median effective concentration (EC50) model estimated dose–volume parameters associated with radiation necrosis. Results Median follow-up time was 31 months (range 6-96 months) and was 34 months in patients who were alive. The Kaplan-Meier estimate of overall survival at 3 years was 84.9%. The 3-year estimate of any grade temporal lobe radiation necrosis was 12.4%, and for grade 2 or higher radiation necrosis was 5.7%. On multivariate GEE, only dose–volume relationships were associated with the risk of radiation necrosis. In the EC50 model, all dose levels from 10 to 70 Gy (RBE) were highly correlated with radiation necrosis, with a 15% 3-year risk of any-grade temporal lobe radiation necrosis when the absolute volume of a temporal lobe receiving 60 Gy (RBE) (aV60) exceeded 5.5 cm3 , or aV70 > 1.7 cm3. Conclusions Dose–volume parameters are highly correlated with the risk of developing temporal lobe radiation necrosis. In this study the risk of radiation necrosis increased sharply when the temporal lobe aV60 exceeded 5.5 cm3 or aV70 > 1.7 cm3 . Treatment planning goals should include constraints on the volume of temporal lobes receiving higher dose. The EC50 model provides suggested dose–volume temporal lobe constraints for conventionally fractionated high-dose skull base radiation therapy.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2014.10.011</identifier><identifier>PMID: 25636754</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; CARCINOMAS ; Causality ; CHEMOTHERAPY ; Cohort Studies ; Comorbidity ; Dose Fractionation ; Dose-Response Relationship, Radiation ; EQUATIONS ; Female ; HAZARDS ; Hematology, Oncology and Palliative Medicine ; Humans ; HYPERTENSION ; Indiana - epidemiology ; Lethal Dose 50 ; LIMITING VALUES ; Male ; Middle Aged ; MULTIVARIATE ANALYSIS ; NECROSIS ; PATIENTS ; PLANNING ; PROTON BEAMS ; Protons - therapeutic use ; RADIATION DOSES ; Radiation Injuries - mortality ; Radiation Injuries - pathology ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOTHERAPY ; Radiotherapy, Conformal ; RBE ; REGRESSION ANALYSIS ; Retrospective Studies ; Risk Factors ; SKULL ; Skull Base Neoplasms - mortality ; Skull Base Neoplasms - pathology ; Skull Base Neoplasms - radiotherapy ; SMOKES ; Survival Rate ; Temporal Lobe - pathology ; Temporal Lobe - radiation effects ; Treatment Outcome ; Tumor Burden - radiation effects ; Young Adult</subject><ispartof>International journal of radiation oncology, biology, physics, 2015-02, Vol.91 (2), p.261-267</ispartof><rights>Elsevier Inc.</rights><rights>2015 Elsevier Inc.</rights><rights>Copyright © 2015 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-630d7d4619d8b091050b20fa4679418e2cf6ce74592d470358f41cc0d4dba3423</citedby><cites>FETCH-LOGICAL-c375t-630d7d4619d8b091050b20fa4679418e2cf6ce74592d470358f41cc0d4dba3423</cites><orcidid>0000-0003-3021-9356</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S036030161404262X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25636754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22458591$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>McDonald, Mark W., MD</creatorcontrib><creatorcontrib>Linton, Okechukwu R., MD, MBA</creatorcontrib><creatorcontrib>Calley, Cynthia S.J., MA</creatorcontrib><title>Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose We evaluated patient and treatment parameters correlated with development of temporal lobe radiation necrosis. Methods and Materials This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignancies between 2005 and 2012, who had at least 6 months of clinical and radiographic follow-up. The median radiation dose was 75.6 Gy (relative biological effectiveness [RBE]). Analyzed factors included gender, age, hypertension, diabetes, smoking status, use of chemotherapy, and the absolute dose:volume data for both the right and left temporal lobes, considered separately. A generalized estimating equation (GEE) regression analysis evaluated potential predictors of radiation necrosis, and the median effective concentration (EC50) model estimated dose–volume parameters associated with radiation necrosis. Results Median follow-up time was 31 months (range 6-96 months) and was 34 months in patients who were alive. The Kaplan-Meier estimate of overall survival at 3 years was 84.9%. The 3-year estimate of any grade temporal lobe radiation necrosis was 12.4%, and for grade 2 or higher radiation necrosis was 5.7%. On multivariate GEE, only dose–volume relationships were associated with the risk of radiation necrosis. In the EC50 model, all dose levels from 10 to 70 Gy (RBE) were highly correlated with radiation necrosis, with a 15% 3-year risk of any-grade temporal lobe radiation necrosis when the absolute volume of a temporal lobe receiving 60 Gy (RBE) (aV60) exceeded 5.5 cm3 , or aV70 > 1.7 cm3. Conclusions Dose–volume parameters are highly correlated with the risk of developing temporal lobe radiation necrosis. In this study the risk of radiation necrosis increased sharply when the temporal lobe aV60 exceeded 5.5 cm3 or aV70 > 1.7 cm3 . Treatment planning goals should include constraints on the volume of temporal lobes receiving higher dose. The EC50 model provides suggested dose–volume temporal lobe constraints for conventionally fractionated high-dose skull base radiation therapy.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>CARCINOMAS</subject><subject>Causality</subject><subject>CHEMOTHERAPY</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Dose Fractionation</subject><subject>Dose-Response Relationship, Radiation</subject><subject>EQUATIONS</subject><subject>Female</subject><subject>HAZARDS</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>HYPERTENSION</subject><subject>Indiana - epidemiology</subject><subject>Lethal Dose 50</subject><subject>LIMITING VALUES</subject><subject>Male</subject><subject>Middle Aged</subject><subject>MULTIVARIATE ANALYSIS</subject><subject>NECROSIS</subject><subject>PATIENTS</subject><subject>PLANNING</subject><subject>PROTON BEAMS</subject><subject>Protons - therapeutic use</subject><subject>RADIATION DOSES</subject><subject>Radiation Injuries - mortality</subject><subject>Radiation Injuries - pathology</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOTHERAPY</subject><subject>Radiotherapy, Conformal</subject><subject>RBE</subject><subject>REGRESSION ANALYSIS</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>SKULL</subject><subject>Skull Base Neoplasms - mortality</subject><subject>Skull Base Neoplasms - pathology</subject><subject>Skull Base Neoplasms - radiotherapy</subject><subject>SMOKES</subject><subject>Survival Rate</subject><subject>Temporal Lobe - pathology</subject><subject>Temporal Lobe - radiation effects</subject><subject>Treatment Outcome</subject><subject>Tumor Burden - radiation effects</subject><subject>Young Adult</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9u1DAQxiMEokvhDRCyxIVLFtuxneSC1Ja_0goQXaA3y7EnWqdOnNoJ0t54B96QJ8EhhQMXTpZGv_lm_H2TZY8J3hJMxPNua7vgm3FLMWGptMWE3Mk2pCrrvOD86m62wYXAeZHgk-xBjB3GCSnZ_eyEclGIkrNNdvPSR_j5_ccX7-Ye0CdwarJ-iAc7RnQWo9dWTWDQVzsd0B760Qfl0M43iVXG_obRe9DBR5sa2gkCuryenUPnKgL6GPyUgHNQPdofIKjx-DC71yoX4dHte5p9fv1qf_E233148-7ibJfrouRTLgpsSsMEqU3V4JpgjhuKW8VEWTNSAdWt0FAyXlPDSlzwqmVEa2yYaVTBaHGaPV11fZysjNpOoA_aDwPoSVLKeMVrkqhnKzUGfzNDnGRvowbn1AB-jpIIThmpiVgE2Youn40BWjkG26twlATLJRLZyTUSuUSyVJPfqe3J7YS56cH8bfqTQQJerAAkN75ZCMuyMGgwNiy7Gm__N-FfAe3sYLVy13CE2Pk5DMlpSWSkEsvL5SyWqyAMMyroVfELkIKz3w</recordid><startdate>20150201</startdate><enddate>20150201</enddate><creator>McDonald, Mark W., MD</creator><creator>Linton, Okechukwu R., MD, MBA</creator><creator>Calley, Cynthia S.J., MA</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope><orcidid>https://orcid.org/0000-0003-3021-9356</orcidid></search><sort><creationdate>20150201</creationdate><title>Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy</title><author>McDonald, Mark W., MD ; Linton, Okechukwu R., MD, MBA ; Calley, Cynthia S.J., MA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-630d7d4619d8b091050b20fa4679418e2cf6ce74592d470358f41cc0d4dba3423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>CARCINOMAS</topic><topic>Causality</topic><topic>CHEMOTHERAPY</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>Dose Fractionation</topic><topic>Dose-Response Relationship, Radiation</topic><topic>EQUATIONS</topic><topic>Female</topic><topic>HAZARDS</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>HYPERTENSION</topic><topic>Indiana - epidemiology</topic><topic>Lethal Dose 50</topic><topic>LIMITING VALUES</topic><topic>Male</topic><topic>Middle Aged</topic><topic>MULTIVARIATE ANALYSIS</topic><topic>NECROSIS</topic><topic>PATIENTS</topic><topic>PLANNING</topic><topic>PROTON BEAMS</topic><topic>Protons - therapeutic use</topic><topic>RADIATION DOSES</topic><topic>Radiation Injuries - mortality</topic><topic>Radiation Injuries - pathology</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOTHERAPY</topic><topic>Radiotherapy, Conformal</topic><topic>RBE</topic><topic>REGRESSION ANALYSIS</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>SKULL</topic><topic>Skull Base Neoplasms - mortality</topic><topic>Skull Base Neoplasms - pathology</topic><topic>Skull Base Neoplasms - radiotherapy</topic><topic>SMOKES</topic><topic>Survival Rate</topic><topic>Temporal Lobe - pathology</topic><topic>Temporal Lobe - radiation effects</topic><topic>Treatment Outcome</topic><topic>Tumor Burden - radiation effects</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McDonald, Mark W., MD</creatorcontrib><creatorcontrib>Linton, Okechukwu R., MD, MBA</creatorcontrib><creatorcontrib>Calley, Cynthia S.J., MA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McDonald, Mark W., MD</au><au>Linton, Okechukwu R., MD, MBA</au><au>Calley, Cynthia S.J., MA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2015-02-01</date><risdate>2015</risdate><volume>91</volume><issue>2</issue><spage>261</spage><epage>267</epage><pages>261-267</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose We evaluated patient and treatment parameters correlated with development of temporal lobe radiation necrosis. Methods and Materials This was a retrospective analysis of a cohort of 66 patients treated for skull base chordoma, chondrosarcoma, adenoid cystic carcinoma, or sinonasal malignancies between 2005 and 2012, who had at least 6 months of clinical and radiographic follow-up. The median radiation dose was 75.6 Gy (relative biological effectiveness [RBE]). Analyzed factors included gender, age, hypertension, diabetes, smoking status, use of chemotherapy, and the absolute dose:volume data for both the right and left temporal lobes, considered separately. A generalized estimating equation (GEE) regression analysis evaluated potential predictors of radiation necrosis, and the median effective concentration (EC50) model estimated dose–volume parameters associated with radiation necrosis. Results Median follow-up time was 31 months (range 6-96 months) and was 34 months in patients who were alive. The Kaplan-Meier estimate of overall survival at 3 years was 84.9%. The 3-year estimate of any grade temporal lobe radiation necrosis was 12.4%, and for grade 2 or higher radiation necrosis was 5.7%. On multivariate GEE, only dose–volume relationships were associated with the risk of radiation necrosis. In the EC50 model, all dose levels from 10 to 70 Gy (RBE) were highly correlated with radiation necrosis, with a 15% 3-year risk of any-grade temporal lobe radiation necrosis when the absolute volume of a temporal lobe receiving 60 Gy (RBE) (aV60) exceeded 5.5 cm3 , or aV70 > 1.7 cm3. Conclusions Dose–volume parameters are highly correlated with the risk of developing temporal lobe radiation necrosis. In this study the risk of radiation necrosis increased sharply when the temporal lobe aV60 exceeded 5.5 cm3 or aV70 > 1.7 cm3 . Treatment planning goals should include constraints on the volume of temporal lobes receiving higher dose. The EC50 model provides suggested dose–volume temporal lobe constraints for conventionally fractionated high-dose skull base radiation therapy.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>25636754</pmid><doi>10.1016/j.ijrobp.2014.10.011</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0003-3021-9356</orcidid></addata></record> |
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| subjects | Adolescent Adult Aged CARCINOMAS Causality CHEMOTHERAPY Cohort Studies Comorbidity Dose Fractionation Dose-Response Relationship, Radiation EQUATIONS Female HAZARDS Hematology, Oncology and Palliative Medicine Humans HYPERTENSION Indiana - epidemiology Lethal Dose 50 LIMITING VALUES Male Middle Aged MULTIVARIATE ANALYSIS NECROSIS PATIENTS PLANNING PROTON BEAMS Protons - therapeutic use RADIATION DOSES Radiation Injuries - mortality Radiation Injuries - pathology Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOTHERAPY Radiotherapy, Conformal RBE REGRESSION ANALYSIS Retrospective Studies Risk Factors SKULL Skull Base Neoplasms - mortality Skull Base Neoplasms - pathology Skull Base Neoplasms - radiotherapy SMOKES Survival Rate Temporal Lobe - pathology Temporal Lobe - radiation effects Treatment Outcome Tumor Burden - radiation effects Young Adult |
| title | Dose–Volume Relationships Associated With Temporal Lobe Radiation Necrosis After Skull Base Proton Beam Therapy |
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