Mechanistic studies of cancer cell mitochondria- and NQO1-mediated redox activation of beta-lapachone, a potentially novel anticancer agent

Beta-lapachone (beta-Lp) derived from the Lapacho tree is a potentially novel anticancer agent currently under clinical trials. Previous studies suggested that redox activation of beta-Lp catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) accounted for its killing of cancer cells. However, the exa...

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Veröffentlicht in:	Toxicology and applied pharmacology 2014-12, Vol.281 (3), p.285-293
Hauptverfasser:	Li, Jason Z., Ke, Yuebin, Misra, Hara P., Trush, Michael A., Li, Y. Robert, Zhu, Hong, Jia, Zhenquan
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Activation, Metabolic - drug effects Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - antagonists & inhibitors Antineoplastic Agents, Phytogenic - metabolism Antineoplastic Agents, Phytogenic - pharmacology BENZOQUINONES Beta-lapachone Biological and medical sciences Cancer cells CELL KILLING Cell Line, Tumor CHEMILUMINESCENCE Chemotherapy CLINICAL TRIALS ELECTRON SPIN RESONANCE Electron Transport Complex I - antagonists & inhibitors Electron Transport Complex I - metabolism Enzyme Inhibitors - pharmacology EPR HEPATOMAS Humans Indolequinones - pharmacology Medical sciences MELANOMAS Mice MITOCHONDRIA Mitochondria - drug effects Mitochondria - enzymology Mitochondria - metabolism Mitochondrial electron transport chain NAD(P)H Dehydrogenase (Quinone) - antagonists & inhibitors NAD(P)H Dehydrogenase (Quinone) - metabolism Naphthoquinones - antagonists & inhibitors Naphthoquinones - metabolism Naphthoquinones - pharmacology Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - metabolism NQO1 Oxidation-Reduction - drug effects OXIDES OXYGEN PEROXIDASES Pharmacology. Drug treatments PHOSPHATES Prodrugs - chemistry Prodrugs - metabolism Prodrugs - pharmacology RADICALS Reactive Oxygen Species - metabolism Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - metabolism Reverse Transcriptase Inhibitors - pharmacology ROS Rotenone - pharmacology SUPEROXIDE DISMUTASE Toxicology
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