Structure-dependent binding and activation of perfluorinated compounds on human peroxisome proliferator-activated receptor γ

Perfluorinated compounds (PFCs) have been shown to disrupt lipid metabolism and even induce cancer in rodents through activation of peroxisome proliferator-activated receptors (PPARs). Lines of evidence showed that PPARα was activated by PFCs. However, the information on the binding interactions bet...

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Veröffentlicht in:	Toxicology and applied pharmacology 2014-09, Vol.279 (3), p.275-283
Hauptverfasser:	Zhang, Lianying, Ren, Xiao-Min, Wan, Bin, Guo, Liang-Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Activation potency AFFINITY ALCOHOLS Binding, Competitive - drug effects Biological and medical sciences CARBON Carboxylic Acids - metabolism Cell Line Cell Survival - drug effects Cells, Cultured Circular Dichroism Coloring Agents Fluorocarbons - metabolism Fluorocarbons - toxicity GEOMETRY Humans IN VITRO LENGTH Ligand binding assay LIGANDS LIPIDS LUCIFERASE Medical sciences METABOLISM Models, Molecular Molecular docking NEOPLASMS PARγ Perfluorinated compounds Peroxisome Proliferator-Activated Receptors - drug effects PPAR gamma - drug effects PPAR gamma - genetics Protein Binding RECEPTORS RODENTS SPECTROSCOPY Structure-Activity Relationship Structure-dependent SULFONIC ACIDS Tetrazolium Salts Thiazoles Toxicology Transfection
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