The chemopreventive activity of the histone deacetylase inhibitor tributyrin in colon carcinogenesis involves the induction of apoptosis and reduction of DNA damage

The chemopreventive activity of the histone deacetylase inhibitor (HDACi) tributyrin (TB), a prodrug of butyric acid (BA), was evaluated in a rat model of colon carcinogenesis. The animals were treated with TB (TB group: 200mg/100g of body weight, b.w.) or maltodextrin (MD isocaloric control group:...

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Veröffentlicht in:	Toxicology and applied pharmacology 2014-04, Vol.276 (2), p.129-135
Hauptverfasser:	Heidor, Renato, Furtado, Kelly Silva, Ortega, Juliana Festa, de Oliveira, Tiago Franco, Tavares, Paulo Eduardo Latorre Martins, Vieira, Alessandra, Miranda, Mayara Lilian Paulino, Purgatto, Eduardo, Moreno, Fernando Salvador
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dimethylhydrazine 60 APPLIED LIFE SCIENCES Aberrant crypt foci ACETYLATION Animals Anticarcinogenic Agents - pharmacology APOPTOSIS Apoptosis - drug effects Biological and medical sciences BUTYRIC ACID CARCINOGENESIS Carcinogenesis, carcinogens and anticarcinogens Chemical agents Colon cancer Colonic Neoplasms - prevention & control COMPARATIVE EVALUATIONS CONCENTRATION RATIO Deoxyguanosine - analogs & derivatives DNA ADDUCTS DNA Damage DNA DAMAGES ECOLOGICAL CONCENTRATION Gastroenterology. Liver. Pancreas. Abdomen Histone acetylation Histone Deacetylase Inhibitors - pharmacology LARGE INTESTINE Male Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) NEOPLASMS Precancerous Conditions - prevention & control RATS Rats, Wistar Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Toxicology Tributyrin Triglycerides - pharmacology Tumors Weight Gain - drug effects
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