The UL24 protein of herpes simplex virus 1 affects the sub-cellular distribution of viral glycoproteins involved in fusion

Abstract Mutations in UL24 of herpes simplex virus type 1 can lead to a syncytial phenotype. We hypothesized that UL24 affects the sub-cellular distribution of viral glycoproteins involved in fusion. In non-immortalized human foreskin fibroblasts (HFFs) we detected viral glycoproteins B (gB), gD, gH...

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Veröffentlicht in:	Virology (New York, N.Y.) N.Y.), 2013-09, Vol.444 (1), p.263-273
Hauptverfasser:	Ben Abdeljelil, Nawel, Rochette, Pierre-Alexandre, Pearson, Angela
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ACTIN Cell Fusion Cells, Cultured CYTOPLASM DISTRIBUTION F-actin FIBROBLASTS Fibroblasts - virology Giant Cells - cytology Giant Cells - virology GLYCOPROTEINS Glycoproteins - metabolism HERPES SIMPLEX Herpes simplex virus 1 Herpesvirus 1, Human - genetics Herpesvirus 1, Human - physiology Humans Infectious Disease Life Sciences MEMBRANES MICROTUBULES Mutant Proteins - genetics Mutant Proteins - metabolism MUTATIONS PHENOTYPE Syncytia UL24 Viral Proteins - genetics Viral Proteins - metabolism VIRUSES
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