Neutralization of interleukin-17A delays progression of silica-induced lung inflammation and fibrosis in C57BL/6 mice

Silica exposure can cause lung inflammation and fibrosis, known as silicosis. Interleukin-17A (IL-17A) and Th17 cells play a pivotal role in controlling inflammatory diseases. However, the roles of IL-17A and Th17 cells in the progress of silica-induced inflammation and fibrosis are poorly understoo...

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Veröffentlicht in:	Toxicology and applied pharmacology 2014-02, Vol.275 (1), p.62-72
Hauptverfasser:	Chen, Ying, Li, Cuiying, Weng, Dong, Song, Laiyu, Tang, Wen, Dai, Wujing, Yu, Ye, Liu, Fangwei, Zhao, Ming, Lu, Chunwei, Chen, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Anti-Inflammatory Agents, Non-Steroidal - therapeutic use ANTIBODIES Antibodies, Neutralizing - therapeutic use Biological and medical sciences Disease Models, Animal Disease Progression Down-Regulation - drug effects Female FIBROSIS IL-17A INFLAMMATION Interleukin-17 - antagonists & inhibitors Interleukin-17 - metabolism Interleukin-1beta - antagonists & inhibitors Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - antagonists & inhibitors Interleukin-6 - genetics Interleukin-6 - metabolism Lung - drug effects Lung - immunology Lung - metabolism Lung - pathology Lung fibrosis Lung Inflammation LUNGS LYMPH NODES Medical sciences MICE Mice, Inbred C57BL Neutrophil Infiltration - drug effects NEUTROPHILS PNEUMOCONIOSES Pneumology Pneumonia - etiology Pneumonia - prevention & control Pulmonary Fibrosis - etiology Pulmonary Fibrosis - prevention & control Random Allocation Respiratory system : syndromes and miscellaneous diseases SILICA Silicosis - drug therapy Silicosis - immunology Silicosis - pathology Silicosis - physiopathology Specific Pathogen-Free Organisms T-Lymphocytes, Helper-Inducer - drug effects T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism T-Lymphocytes, Helper-Inducer - pathology T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism T-Lymphocytes, Regulatory - pathology Th17 Toxicology
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