Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer
Purpose To measure the relative biological effectiveness (RBE) of carbon ions in the rat spinal cord as a function of linear energy transfer (LET). Methods and Materials As an extension of a previous study, the cervical spinal cord of rats was irradiated with single doses of carbon ions at 6 positio...
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| Veröffentlicht in: | International journal of radiation oncology, biology, physics biology, physics, 2014-09, Vol.90 (1), p.63-70 |
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| creator | Saager, Maria, MSc Glowa, Christin, PhD Peschke, Peter, PhD Brons, Stephan, PhD Scholz, Michael, PhD Huber, Peter E., MD, PhD Debus, Jürgen, MD, PhD Karger, Christian P., PhD |
| description | Purpose To measure the relative biological effectiveness (RBE) of carbon ions in the rat spinal cord as a function of linear energy transfer (LET). Methods and Materials As an extension of a previous study, the cervical spinal cord of rats was irradiated with single doses of carbon ions at 6 positions of a 6-cm spread-out Bragg peak (16-99 keV/μm). The TD50 values (dose at 50% complication probability) were determined according to dose-response curves for the development of paresis grade 2 within an observation time of 300 days. The RBEs were calculated using TD50 for photons of our previous study. Results Minimum latency time was found to be dose-dependent, but not significantly LET-dependent. The TD50 values for the onset of paresis grade 2 within 300 days were 19.5 ± 0.4 Gy (16 keV/μm), 18.4 ± 0.4 Gy (21 keV/μm), 17.7 ± 0.3 Gy (36 keV/μm), 16.1 ± 1.2 Gy (45 keV/μm), 14.6 ± 0.5 Gy (66 keV/μm), and 14.8 ± 0.5 Gy (99 keV/μm). The corresponding RBEs increased from 1.26 ± 0.05 (16 keV/μm) up to 1.68 ± 0.08 at 66 keV/μm. Unexpectedly, the RBE at 99 keV/μm was comparable to that at 66 keV/μm. Conclusions The data suggest a linear relation between RBE and LET at high doses for late effects in the spinal cord. Together with additional data from ongoing fractionated irradiation experiments, these data will provide an extended database to systematically benchmark RBE models for further improvements of carbon ion treatment planning. |
| doi_str_mv | 10.1016/j.ijrobp.2014.05.008 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22420409</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0360301614005926</els_id><sourcerecordid>1561036264</sourcerecordid><originalsourceid>FETCH-LOGICAL-c581t-9f8002fece082a39db1425e460bbad01df04bb9a242414dcabc58e47d9c21bf13</originalsourceid><addsrcrecordid>eNqFksGL1DAUxoso7rj6H4gEvHhpfUnTTuNB0HHUhQHBXcFbSJPX3dROMpt0Fgb8403ougcvHkJC-H3fe3lfiuIlhYoCbd-OlR2D7w8VA8oraCqA7lGxot1alHXT_HxcrKBuoawTfFY8i3EEAErX_GlxxrgQXSf4qvi9UaH3jlzkFYIyVs02nf1A5hsk39VMLg_WqYlsfDDvyCc8oDPoND4gOCXJHZKP1k_-2urEbocBdb50GCNJdjvrUAWydRiuT-QqKBcHDM-LJ4OaIr6438-LH5-3V5uv5e7bl4vNh12pm47OpRg6AJYcETqmamF6ylmDvIW-VwaoGYD3vVCMM0650apPOuRrIzSj_UDr8-L14uvjbGXUdkZ9o71zqUnJkgw4iES9WahD8LdHjLPc26hxmpRDf4ySNi1NE2UtTyhfUB18jAEHeQh2r8JJUpA5HTnKJR2Z05HQyJROkr26r3Ds92geRH_jSMD7BcA0jTuLITebh21syL0ab_9X4V8DPVmXM_mFJ4yjP4aUZXqLjEyCvMw_JH8QygEawdr6DwgCt6g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1561036264</pqid></control><display><type>article</type><title>Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Saager, Maria, MSc ; Glowa, Christin, PhD ; Peschke, Peter, PhD ; Brons, Stephan, PhD ; Scholz, Michael, PhD ; Huber, Peter E., MD, PhD ; Debus, Jürgen, MD, PhD ; Karger, Christian P., PhD</creator><creatorcontrib>Saager, Maria, MSc ; Glowa, Christin, PhD ; Peschke, Peter, PhD ; Brons, Stephan, PhD ; Scholz, Michael, PhD ; Huber, Peter E., MD, PhD ; Debus, Jürgen, MD, PhD ; Karger, Christian P., PhD</creatorcontrib><description>Purpose To measure the relative biological effectiveness (RBE) of carbon ions in the rat spinal cord as a function of linear energy transfer (LET). Methods and Materials As an extension of a previous study, the cervical spinal cord of rats was irradiated with single doses of carbon ions at 6 positions of a 6-cm spread-out Bragg peak (16-99 keV/μm). The TD50 values (dose at 50% complication probability) were determined according to dose-response curves for the development of paresis grade 2 within an observation time of 300 days. The RBEs were calculated using TD50 for photons of our previous study. Results Minimum latency time was found to be dose-dependent, but not significantly LET-dependent. The TD50 values for the onset of paresis grade 2 within 300 days were 19.5 ± 0.4 Gy (16 keV/μm), 18.4 ± 0.4 Gy (21 keV/μm), 17.7 ± 0.3 Gy (36 keV/μm), 16.1 ± 1.2 Gy (45 keV/μm), 14.6 ± 0.5 Gy (66 keV/μm), and 14.8 ± 0.5 Gy (99 keV/μm). The corresponding RBEs increased from 1.26 ± 0.05 (16 keV/μm) up to 1.68 ± 0.08 at 66 keV/μm. Unexpectedly, the RBE at 99 keV/μm was comparable to that at 66 keV/μm. Conclusions The data suggest a linear relation between RBE and LET at high doses for late effects in the spinal cord. Together with additional data from ongoing fractionated irradiation experiments, these data will provide an extended database to systematically benchmark RBE models for further improvements of carbon ion treatment planning.</description><identifier>ISSN: 0360-3016</identifier><identifier>EISSN: 1879-355X</identifier><identifier>DOI: 10.1016/j.ijrobp.2014.05.008</identifier><identifier>PMID: 24998894</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Body Weight - radiation effects ; BRAGG CURVE ; CARBON IONS ; Carbon Radioisotopes ; Cervical Vertebrae ; COMPARATIVE EVALUATIONS ; Dose-Response Relationship, Radiation ; Female ; FRACTIONATED IRRADIATION ; Hematology, Oncology and Palliative Medicine ; LET ; Linear Energy Transfer ; Paresis - etiology ; Photons ; PLANNING ; RADIATION DOSES ; Radiology ; RADIOLOGY AND NUCLEAR MEDICINE ; RATS ; Rats, Sprague-Dawley ; RBE ; Relative Biological Effectiveness ; SPINAL CORD ; Spinal Cord - radiation effects ; Time Factors</subject><ispartof>International journal of radiation oncology, biology, physics, 2014-09, Vol.90 (1), p.63-70</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c581t-9f8002fece082a39db1425e460bbad01df04bb9a242414dcabc58e47d9c21bf13</citedby><cites>FETCH-LOGICAL-c581t-9f8002fece082a39db1425e460bbad01df04bb9a242414dcabc58e47d9c21bf13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0360301614005926$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24998894$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22420409$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Saager, Maria, MSc</creatorcontrib><creatorcontrib>Glowa, Christin, PhD</creatorcontrib><creatorcontrib>Peschke, Peter, PhD</creatorcontrib><creatorcontrib>Brons, Stephan, PhD</creatorcontrib><creatorcontrib>Scholz, Michael, PhD</creatorcontrib><creatorcontrib>Huber, Peter E., MD, PhD</creatorcontrib><creatorcontrib>Debus, Jürgen, MD, PhD</creatorcontrib><creatorcontrib>Karger, Christian P., PhD</creatorcontrib><title>Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer</title><title>International journal of radiation oncology, biology, physics</title><addtitle>Int J Radiat Oncol Biol Phys</addtitle><description>Purpose To measure the relative biological effectiveness (RBE) of carbon ions in the rat spinal cord as a function of linear energy transfer (LET). Methods and Materials As an extension of a previous study, the cervical spinal cord of rats was irradiated with single doses of carbon ions at 6 positions of a 6-cm spread-out Bragg peak (16-99 keV/μm). The TD50 values (dose at 50% complication probability) were determined according to dose-response curves for the development of paresis grade 2 within an observation time of 300 days. The RBEs were calculated using TD50 for photons of our previous study. Results Minimum latency time was found to be dose-dependent, but not significantly LET-dependent. The TD50 values for the onset of paresis grade 2 within 300 days were 19.5 ± 0.4 Gy (16 keV/μm), 18.4 ± 0.4 Gy (21 keV/μm), 17.7 ± 0.3 Gy (36 keV/μm), 16.1 ± 1.2 Gy (45 keV/μm), 14.6 ± 0.5 Gy (66 keV/μm), and 14.8 ± 0.5 Gy (99 keV/μm). The corresponding RBEs increased from 1.26 ± 0.05 (16 keV/μm) up to 1.68 ± 0.08 at 66 keV/μm. Unexpectedly, the RBE at 99 keV/μm was comparable to that at 66 keV/μm. Conclusions The data suggest a linear relation between RBE and LET at high doses for late effects in the spinal cord. Together with additional data from ongoing fractionated irradiation experiments, these data will provide an extended database to systematically benchmark RBE models for further improvements of carbon ion treatment planning.</description><subject>Animals</subject><subject>Body Weight - radiation effects</subject><subject>BRAGG CURVE</subject><subject>CARBON IONS</subject><subject>Carbon Radioisotopes</subject><subject>Cervical Vertebrae</subject><subject>COMPARATIVE EVALUATIONS</subject><subject>Dose-Response Relationship, Radiation</subject><subject>Female</subject><subject>FRACTIONATED IRRADIATION</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>LET</subject><subject>Linear Energy Transfer</subject><subject>Paresis - etiology</subject><subject>Photons</subject><subject>PLANNING</subject><subject>RADIATION DOSES</subject><subject>Radiology</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>RBE</subject><subject>Relative Biological Effectiveness</subject><subject>SPINAL CORD</subject><subject>Spinal Cord - radiation effects</subject><subject>Time Factors</subject><issn>0360-3016</issn><issn>1879-355X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGL1DAUxoso7rj6H4gEvHhpfUnTTuNB0HHUhQHBXcFbSJPX3dROMpt0Fgb8403ougcvHkJC-H3fe3lfiuIlhYoCbd-OlR2D7w8VA8oraCqA7lGxot1alHXT_HxcrKBuoawTfFY8i3EEAErX_GlxxrgQXSf4qvi9UaH3jlzkFYIyVs02nf1A5hsk39VMLg_WqYlsfDDvyCc8oDPoND4gOCXJHZKP1k_-2urEbocBdb50GCNJdjvrUAWydRiuT-QqKBcHDM-LJ4OaIr6438-LH5-3V5uv5e7bl4vNh12pm47OpRg6AJYcETqmamF6ylmDvIW-VwaoGYD3vVCMM0650apPOuRrIzSj_UDr8-L14uvjbGXUdkZ9o71zqUnJkgw4iES9WahD8LdHjLPc26hxmpRDf4ySNi1NE2UtTyhfUB18jAEHeQh2r8JJUpA5HTnKJR2Z05HQyJROkr26r3Ds92geRH_jSMD7BcA0jTuLITebh21syL0ab_9X4V8DPVmXM_mFJ4yjP4aUZXqLjEyCvMw_JH8QygEawdr6DwgCt6g</recordid><startdate>20140901</startdate><enddate>20140901</enddate><creator>Saager, Maria, MSc</creator><creator>Glowa, Christin, PhD</creator><creator>Peschke, Peter, PhD</creator><creator>Brons, Stephan, PhD</creator><creator>Scholz, Michael, PhD</creator><creator>Huber, Peter E., MD, PhD</creator><creator>Debus, Jürgen, MD, PhD</creator><creator>Karger, Christian P., PhD</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>20140901</creationdate><title>Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer</title><author>Saager, Maria, MSc ; Glowa, Christin, PhD ; Peschke, Peter, PhD ; Brons, Stephan, PhD ; Scholz, Michael, PhD ; Huber, Peter E., MD, PhD ; Debus, Jürgen, MD, PhD ; Karger, Christian P., PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c581t-9f8002fece082a39db1425e460bbad01df04bb9a242414dcabc58e47d9c21bf13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Animals</topic><topic>Body Weight - radiation effects</topic><topic>BRAGG CURVE</topic><topic>CARBON IONS</topic><topic>Carbon Radioisotopes</topic><topic>Cervical Vertebrae</topic><topic>COMPARATIVE EVALUATIONS</topic><topic>Dose-Response Relationship, Radiation</topic><topic>Female</topic><topic>FRACTIONATED IRRADIATION</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>LET</topic><topic>Linear Energy Transfer</topic><topic>Paresis - etiology</topic><topic>Photons</topic><topic>PLANNING</topic><topic>RADIATION DOSES</topic><topic>Radiology</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>RBE</topic><topic>Relative Biological Effectiveness</topic><topic>SPINAL CORD</topic><topic>Spinal Cord - radiation effects</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saager, Maria, MSc</creatorcontrib><creatorcontrib>Glowa, Christin, PhD</creatorcontrib><creatorcontrib>Peschke, Peter, PhD</creatorcontrib><creatorcontrib>Brons, Stephan, PhD</creatorcontrib><creatorcontrib>Scholz, Michael, PhD</creatorcontrib><creatorcontrib>Huber, Peter E., MD, PhD</creatorcontrib><creatorcontrib>Debus, Jürgen, MD, PhD</creatorcontrib><creatorcontrib>Karger, Christian P., PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>International journal of radiation oncology, biology, physics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saager, Maria, MSc</au><au>Glowa, Christin, PhD</au><au>Peschke, Peter, PhD</au><au>Brons, Stephan, PhD</au><au>Scholz, Michael, PhD</au><au>Huber, Peter E., MD, PhD</au><au>Debus, Jürgen, MD, PhD</au><au>Karger, Christian P., PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer</atitle><jtitle>International journal of radiation oncology, biology, physics</jtitle><addtitle>Int J Radiat Oncol Biol Phys</addtitle><date>2014-09-01</date><risdate>2014</risdate><volume>90</volume><issue>1</issue><spage>63</spage><epage>70</epage><pages>63-70</pages><issn>0360-3016</issn><eissn>1879-355X</eissn><abstract>Purpose To measure the relative biological effectiveness (RBE) of carbon ions in the rat spinal cord as a function of linear energy transfer (LET). Methods and Materials As an extension of a previous study, the cervical spinal cord of rats was irradiated with single doses of carbon ions at 6 positions of a 6-cm spread-out Bragg peak (16-99 keV/μm). The TD50 values (dose at 50% complication probability) were determined according to dose-response curves for the development of paresis grade 2 within an observation time of 300 days. The RBEs were calculated using TD50 for photons of our previous study. Results Minimum latency time was found to be dose-dependent, but not significantly LET-dependent. The TD50 values for the onset of paresis grade 2 within 300 days were 19.5 ± 0.4 Gy (16 keV/μm), 18.4 ± 0.4 Gy (21 keV/μm), 17.7 ± 0.3 Gy (36 keV/μm), 16.1 ± 1.2 Gy (45 keV/μm), 14.6 ± 0.5 Gy (66 keV/μm), and 14.8 ± 0.5 Gy (99 keV/μm). The corresponding RBEs increased from 1.26 ± 0.05 (16 keV/μm) up to 1.68 ± 0.08 at 66 keV/μm. Unexpectedly, the RBE at 99 keV/μm was comparable to that at 66 keV/μm. Conclusions The data suggest a linear relation between RBE and LET at high doses for late effects in the spinal cord. Together with additional data from ongoing fractionated irradiation experiments, these data will provide an extended database to systematically benchmark RBE models for further improvements of carbon ion treatment planning.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24998894</pmid><doi>10.1016/j.ijrobp.2014.05.008</doi><tpages>8</tpages></addata></record> |
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| subjects | Animals Body Weight - radiation effects BRAGG CURVE CARBON IONS Carbon Radioisotopes Cervical Vertebrae COMPARATIVE EVALUATIONS Dose-Response Relationship, Radiation Female FRACTIONATED IRRADIATION Hematology, Oncology and Palliative Medicine LET Linear Energy Transfer Paresis - etiology Photons PLANNING RADIATION DOSES Radiology RADIOLOGY AND NUCLEAR MEDICINE RATS Rats, Sprague-Dawley RBE Relative Biological Effectiveness SPINAL CORD Spinal Cord - radiation effects Time Factors |
| title | Carbon Ion Irradiation of the Rat Spinal Cord: Dependence of the Relative Biological Effectiveness on Linear Energy Transfer |
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