Inhibition of adipogenesis and leptin production in 3T3-L1 adipocytes by a derivative of meridianin C

•Compound 7b, a meridianin C derivative, inhibits adipogenesis.•Compound 7b inhibits C/EBP-α, PPAR-γ, FAS, STAT-3, and STAT-5 in 3T3-L1 adipocytes.•Compound 7b inhibits leptin, but not adiponectin, expression in 3T3-L1 adipocytes.•Compound 7b thus may have therapeutic potential against obesity. Meri...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 2014-10, Vol.452 (4), p.1078-1083
Hauptverfasser:	Park, Yu-Kyoung, Lee, Tae-Yoon, Choi, Jong-Soon, Hong, Victor Sukbong, Lee, Jinho, Park, Jong-Wook, Jang, Byeong-Churl
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells 60 APPLIED LIFE SCIENCES ADENOSINE Adipocytes - drug effects Adipocytes - metabolism Adipogenesis Adipogenesis - drug effects Adipogenesis - physiology ALKALOIDS AMP Animals Apoptosis - drug effects Apoptosis - physiology C/EBP-α CARBOXYLIC ACIDS Cell Survival - drug effects Cell Survival - physiology HUMAN POPULATIONS Indole Alkaloids - pharmacology INHIBITION LEPTIN Leptin - biosynthesis LEUKEMIA LEUKEMIA VIRUSES Lipid Metabolism - drug effects Lipid Metabolism - physiology LIPIDS Meridianin C derivative METABOLIC DISEASES Mice PHOSPHORYLATION PHOSPHOTRANSFERASES PPAR-γ RECEPTORS STAT-3/5 TRANSCRIPTION TRANSDUCERS
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!