Baicalin prevents Candida albicans infections via increasing its apoptosis rate

•Baicalin increases the ratio of the G0/G1 stages and C. albicans apoptosis.•Baicalin decreases the proliferation index of C. albicans.•Baicalin inhibits the biosynthesis of DNA, RNA and protein in C. albicans.•Baicalin depresses Succinate Dehydrogenase and Ca2+–Mg2+ ATPase in C. albicans.•Baicalin...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-08, Vol.451 (1), p.36-41
Hauptverfasser:	Yang, Shulong, Fu, Yingyuan, Wu, Xiuzhen, Zhou, Zhixing, Xu, Jing, Zeng, Xiaoping, Kuang, Nanzhen, Zeng, Yurong
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Anti-Infective Agents - pharmacology APOPTOSIS Apoptosis - drug effects Baicalin BIOSYNTHESIS Ca(2+) Mg(2+)-ATPase - antagonists & inhibitors Calcium - metabolism CALCIUM IONS CANDIDA Candida albicans Candida albicans - drug effects Candida albicans - genetics Candida albicans - metabolism Candida albicans - ultrastructure Candidiasis - prevention & control CELL CYCLE Cell Cycle - drug effects CELL PROLIFERATION CONCENTRATION RATIO CYTOCHROME OXIDASE DNA DNA, Fungal - biosynthesis Drug target DRUGS ELECTRONS Flavonoids - pharmacology INCUBATION INHIBITION LEUCINE PRECURSOR RNA RNA, Fungal - biosynthesis Succinate Dehydrogenase - antagonists & inhibitors TRITIUM
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