Microparticles generated during chronic cerebral ischemia deliver proapoptotic signals to cultured endothelial cells

•Microparticles are elevated in the plasma in a rodent model of chronic cerebral ischemia.•These microparticles initiate apoptosis in cultured cells.•Microparticles contain caspase 3 and they activate receptors for TNF-α and TRAIL. Circulating microparticles (MPs) are involved in many physiological...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-07, Vol.450 (1), p.912-917
Hauptverfasser:	Schock, Sarah C., Edrissi, Hamidreza, Burger, Dylan, Cadonic, Robert, Hakim, Antoine, Thompson, Charlie
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANTIBODIES APOPTOSIS Apoptosis Regulatory Proteins - metabolism BLOOD PLASMA Brain Ischemia - metabolism Caspase 3 - metabolism Cell Communication CELL CULTURES Cell Survival Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - pathology Cells, Cultured Cerebral ischemia Chronic Disease DOSES ELECTRON MICROSCOPY Endothelial Cells - metabolism Endothelial Cells - pathology INHIBITION ISCHEMIA KIDNEYS Male Microparticles OXIDATION Particle Size RATS Rats, Long-Evans RECEPTORS Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Receptors, Tumor Necrosis Factor - metabolism TNF-α TRAIL Tumor Necrosis Factor-alpha - metabolism
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