Fission yeast LAMMER kinase Lkh1 regulates the cell cycle by phosphorylating the CDK-inhibitor Rum1

► Deletion of lkh1+ made cells pass the G1/S phase faster than the wild type. ► Lkh1 can interact with a cyclin-dependent kinase inhibitor (CKI) Rum1. ► Lkh1 can phosphorylate Rum1 to activate its CKI activity. ► Thr110 was confirmed as the Lkh1-dependent phosphorylation site of Rum1. ► Positive act...

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Veröffentlicht in:	Biochemical and biophysical research communications 2013-03, Vol.432 (1), p.80-85
Hauptverfasser:	Yu, Eun-Young, Lee, Ju-Hee, Kang, Won-Hwa, Park, Yun-Hee, Kim, Lila, Park, Hee-Moon
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES AMINO ACIDS CELL CYCLE Cell Cycle - genetics Cell Separation Cyclin-dependent kinase inhibitor Cyclin-Dependent Kinases - antagonists & inhibitors Fission yeast Flow Cytometry G1 Phase Cell Cycle Checkpoints - genetics Gene Deletion GENES IN VITRO LAMMER kinase Lkh1 MOLECULES MUTANTS Nitrogen - deficiency PEPTIDES PHOSPHORYLATION PHOSPHOTRANSFERASES Protein Kinases - genetics Protein Kinases - metabolism RESIDUES Rum1 Schizosaccharomyces - cytology Schizosaccharomyces - enzymology Schizosaccharomyces pombe Schizosaccharomyces pombe Proteins - genetics Schizosaccharomyces pombe Proteins - metabolism YEASTS
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