$Outcomes and Toxicity for Hypofractionated and Single-Fraction Image-Guided Stereotactic Radiosurgery for Sarcomas Metastasizing to the Spine$

Outcomes and Toxicity for Hypofractionated and Single-Fraction Image-Guided Stereotactic Radiosurgery for Sarcomas Metastasizing to the Spine

Purpose Conventional radiation treatment (20-40 Gy in 5-20 fractions, 2-5 Gy per fraction) for sarcoma metastatic to the spine provides subtherapeutic doses, resulting in poor durable local control (LC) (50%-77% at 1 year). Hypofractionated (HF) and/or single-fraction (SF) image-guided stereotactic...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2014-04, Vol.88 (5), p.1085-1091
Hauptverfasser:	Folkert, Michael R., MD, PhD, Bilsky, Mark H., MD, Tom, Ashlyn K., BA, Oh, Jung Hun, PhD, Alektiar, Kaled M., MD, Laufer, Ilya, MD, Tap, William D., MD, Yamada, Yoshiya, MD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Cohort Studies Dose Fractionation Female HAZARDS Hematology, Oncology and Palliative Medicine Humans Male METASTASES Middle Aged MULTIVARIATE ANALYSIS Neoplasm Metastasis PATIENTS Prognosis Proportional Hazards Models RADIATION DOSES Radiation Injuries - diagnosis Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIVITY Radiosurgery - adverse effects Radiosurgery - methods RADIOTHERAPY Radiotherapy Dosage RISK ASSESSMENT Sarcoma - mortality Sarcoma - pathology Sarcoma - surgery SARCOMAS Spinal Neoplasms - mortality Spinal Neoplasms - secondary Spinal Neoplasms - surgery SURGERY TOXICITY Treatment Outcome VERTEBRAE
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