MicroRNA-223 Enhances Radiation Sensitivity of U87MG Cells In Vitro and In Vivo by Targeting Ataxia Telangiectasia Mutated

Purpose Ataxia telangiectasia mutated (ATM) protein is important in the DNA damage response because it repairs radiation-induced damage in cancers. We examined the effect of microRNA-223 (miR-223), a regulator of ATM expression, on radiation sensitivity of cancer cells. Methods and Materials Human e...

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Veröffentlicht in:	International journal of radiation oncology, biology, physics biology, physics, 2014-03, Vol.88 (4), p.955-960
Hauptverfasser:	Liang, Liping, MD, Zhu, Ji, MD, PhD, Zaorsky, Nicholas G., MD, Deng, Yun, MD, Wu, Xingzhong, PhD, Liu, Yong, PhD, Liu, Fangqi, MD, Cai, Guoxiang, MD, PhD, Gu, Weilie, MD, Shen, Lijun, MD, Zhang, Zhen, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIN Animals Ataxia Telangiectasia Mutated Proteins - metabolism Cell Line, Tumor COMPARATIVE EVALUATIONS DNA DAMAGES Down Syndrome Genes, Reporter Hematology, Oncology and Palliative Medicine Heterografts Humans IN VITRO IN VIVO IRRADIATION KIDNEYS Lentivirus LUCIFERASE Luciferases - metabolism MESSENGER-RNA MICE Mice, Inbred BALB C Mice, Nude MicroRNAs - physiology NEOPLASMS PATIENTS Radiation Tolerance - physiology Radiology RADIOLOGY AND NUCLEAR MEDICINE RADIOSENSITIVITY VIRUSES
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