miR-30a suppresses breast cancer cell proliferation and migration by targeting Eya2

•miR-30a represses Eya2 expression by binding to the 3′-untranslated region of Eya2.•The miR-30a/EYA2 axis regulates breast cancer cell proliferation and migration.•The miR-30a/EYA2 axis modulates G1/S cell cycle progression.•The miR-30a/EYA2 axis is dysregulated in breast cancer patients. Eye absen...

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Veröffentlicht in:	Biochemical and biophysical research communications 2014-03, Vol.445 (2), p.314-319
Hauptverfasser:	Fu, Jing, Xu, Xiaojie, Kang, Lei, Zhou, Liying, Wang, Shibin, Lu, Juming, Cheng, Long, Fan, Zhongyi, Yuan, Bin, Tian, Peirong, Zheng, Xiaofei, Yu, Chengze, Ye, Qinong, Lv, Zhaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions 60 APPLIED LIFE SCIENCES ANIMAL TISSUES Breast - metabolism Breast - pathology Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology CELL CYCLE Cell migration Cell Movement CELL PROLIFERATION Down-Regulation Eya2 Female G1 Phase Cell Cycle Checkpoints Gene Expression Regulation, Neoplastic Humans INHIBITION Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism MAMMARY GLANDS MicroRNAs - genetics MicroRNAs - metabolism MIGRATION miR-30a NEOPLASMS Nuclear Proteins - genetics Nuclear Proteins - metabolism PATIENTS Protein Tyrosine Phosphatases - genetics Protein Tyrosine Phosphatases - metabolism PROTEINS RNA
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