MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)
•The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date.•We found that the expression of miR-361-5p in CRPC was lower than in ADPC.•MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis.•STAT6 is a direct target of miR-361-5p.•STAT6 enhances the expression...
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| Veröffentlicht in: | Biochemical and biophysical research communications 2014-02, Vol.445 (1), p.151-156 |
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| creator | Liu, Dachuang Tao, Tao Xu, Bin Chen, Shuqiu Liu, Chunhui Zhang, Lei Lu, Kai Huang, Yeqing Jiang, Liang Zhang, Xiaowen Huang, Xiaoming Zhang, Lihua Han, Conghui Chen, Ming |
| description | •The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date.•We found that the expression of miR-361-5p in CRPC was lower than in ADPC.•MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis.•STAT6 is a direct target of miR-361-5p.•STAT6 enhances the expression of Bcl-xL at the transcriptional level.
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa. |
| doi_str_mv | 10.1016/j.bbrc.2014.01.140 |
| format | Article |
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Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1016/j.bbrc.2014.01.140</identifier><identifier>PMID: 24491557</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>3' Untranslated Regions - genetics ; 60 APPLIED LIFE SCIENCES ; ANDROGENS ; Animals ; APOPTOSIS ; bcl-X Protein - genetics ; bcl-X Protein - metabolism ; Bcl-xL ; Blotting, Western ; BORON CHLORIDES ; CASTRATION ; Castration-resistant prostate cancer (CRPC) ; Cell Line, Tumor ; CELL PROLIFERATION ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Humans ; LYMPHOMAS ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs - genetics ; miR-361-5p ; Mutation ; Oligonucleotide Array Sequence Analysis ; PATHOGENESIS ; PROSTATE ; Prostatic Neoplasms - genetics ; Prostatic Neoplasms - metabolism ; Prostatic Neoplasms - pathology ; Prostatic Neoplasms, Castration-Resistant - genetics ; Prostatic Neoplasms, Castration-Resistant - metabolism ; Prostatic Neoplasms, Castration-Resistant - pathology ; Reverse Transcriptase Polymerase Chain Reaction ; RNA Interference ; STAT6 ; STAT6 Transcription Factor - genetics ; STAT6 Transcription Factor - metabolism ; TRANSCRIPTION ; TRANSDUCERS ; Tumor Suppressor Proteins - genetics ; Xenograft Model Antitumor Assays</subject><ispartof>Biochemical and biophysical research communications, 2014-02, Vol.445 (1), p.151-156</ispartof><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-bb572eee812a76405415b10b019a7dc374224f08f71854305d765afa7451b5463</citedby><cites>FETCH-LOGICAL-c483t-bb572eee812a76405415b10b019a7dc374224f08f71854305d765afa7451b5463</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0006291X14001752$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24491557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22416293$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Dachuang</creatorcontrib><creatorcontrib>Tao, Tao</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><creatorcontrib>Chen, Shuqiu</creatorcontrib><creatorcontrib>Liu, Chunhui</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Lu, Kai</creatorcontrib><creatorcontrib>Huang, Yeqing</creatorcontrib><creatorcontrib>Jiang, Liang</creatorcontrib><creatorcontrib>Zhang, Xiaowen</creatorcontrib><creatorcontrib>Huang, Xiaoming</creatorcontrib><creatorcontrib>Zhang, Lihua</creatorcontrib><creatorcontrib>Han, Conghui</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><title>MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>•The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date.•We found that the expression of miR-361-5p in CRPC was lower than in ADPC.•MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis.•STAT6 is a direct target of miR-361-5p.•STAT6 enhances the expression of Bcl-xL at the transcriptional level.
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.</description><subject>3' Untranslated Regions - genetics</subject><subject>60 APPLIED LIFE SCIENCES</subject><subject>ANDROGENS</subject><subject>Animals</subject><subject>APOPTOSIS</subject><subject>bcl-X Protein - genetics</subject><subject>bcl-X Protein - metabolism</subject><subject>Bcl-xL</subject><subject>Blotting, Western</subject><subject>BORON CHLORIDES</subject><subject>CASTRATION</subject><subject>Castration-resistant prostate cancer (CRPC)</subject><subject>Cell Line, Tumor</subject><subject>CELL PROLIFERATION</subject><subject>Gene Expression Profiling</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Humans</subject><subject>LYMPHOMAS</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>miR-361-5p</subject><subject>Mutation</subject><subject>Oligonucleotide Array Sequence Analysis</subject><subject>PATHOGENESIS</subject><subject>PROSTATE</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Prostatic Neoplasms - metabolism</subject><subject>Prostatic Neoplasms - pathology</subject><subject>Prostatic Neoplasms, Castration-Resistant - genetics</subject><subject>Prostatic Neoplasms, Castration-Resistant - metabolism</subject><subject>Prostatic Neoplasms, Castration-Resistant - pathology</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA Interference</subject><subject>STAT6</subject><subject>STAT6 Transcription Factor - genetics</subject><subject>STAT6 Transcription Factor - metabolism</subject><subject>TRANSCRIPTION</subject><subject>TRANSDUCERS</subject><subject>Tumor Suppressor Proteins - genetics</subject><subject>Xenograft Model Antitumor Assays</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoTjv6B1xIwM24qPLeVB5d4GYYfAyMCNqCu5BKpdo03akySQ3Myr9uihpdjhBI4H7nkHMPIS8RagSUbw9110VbM0BeA9bI4RHZILRQMQT-mGwAQFasxR9n5FlKBwBELtun5Ixx3qIQakN-f_Zfq0ZiJSZqbE7UlEPzfBojTfM0RZdSefpApzimbLKj1gTrIu3uaDZx77IPe5r8PpgjzdGE1M_L2IR-MfS3Jhf9OKwzG_2U_RgqefFtd7mTb56TJ4M5Jvfi_j4n3z-83119qm6-fLy-urypLN82ueo6oZhzbovMKMlBcBQdQgfYGtXbRnHG-ADbQeFW8AZEr6Qwg1FcYCe4bM7J69W3hPA6WZ-d_WnHEJzNumhRsrYp1MVKlbC_ZpeyPvlk3fFoghvnpFHKLZMAbft_VED5I2uVKihbUVtWmKIb9BT9ycQ7jaCXJvVBL03qpUkNqEuTRfTq3n_uTq7_J_lbXQHerYAra7v1Li6pXKmm93EJ1Y_-If8_Dues2g</recordid><startdate>20140228</startdate><enddate>20140228</enddate><creator>Liu, Dachuang</creator><creator>Tao, Tao</creator><creator>Xu, Bin</creator><creator>Chen, Shuqiu</creator><creator>Liu, Chunhui</creator><creator>Zhang, Lei</creator><creator>Lu, Kai</creator><creator>Huang, Yeqing</creator><creator>Jiang, Liang</creator><creator>Zhang, Xiaowen</creator><creator>Huang, Xiaoming</creator><creator>Zhang, Lihua</creator><creator>Han, Conghui</creator><creator>Chen, Ming</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TO</scope><scope>H94</scope><scope>OTOTI</scope></search><sort><creationdate>20140228</creationdate><title>MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)</title><author>Liu, Dachuang ; Tao, Tao ; Xu, Bin ; Chen, Shuqiu ; Liu, Chunhui ; Zhang, Lei ; Lu, Kai ; Huang, Yeqing ; Jiang, Liang ; Zhang, Xiaowen ; Huang, Xiaoming ; Zhang, Lihua ; Han, Conghui ; Chen, Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-bb572eee812a76405415b10b019a7dc374224f08f71854305d765afa7451b5463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>60 APPLIED LIFE SCIENCES</topic><topic>ANDROGENS</topic><topic>Animals</topic><topic>APOPTOSIS</topic><topic>bcl-X Protein - genetics</topic><topic>bcl-X Protein - metabolism</topic><topic>Bcl-xL</topic><topic>Blotting, Western</topic><topic>BORON CHLORIDES</topic><topic>CASTRATION</topic><topic>Castration-resistant prostate cancer (CRPC)</topic><topic>Cell Line, Tumor</topic><topic>CELL PROLIFERATION</topic><topic>Gene Expression Profiling</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Humans</topic><topic>LYMPHOMAS</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>MicroRNAs - genetics</topic><topic>miR-361-5p</topic><topic>Mutation</topic><topic>Oligonucleotide Array Sequence Analysis</topic><topic>PATHOGENESIS</topic><topic>PROSTATE</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Prostatic Neoplasms - metabolism</topic><topic>Prostatic Neoplasms - pathology</topic><topic>Prostatic Neoplasms, Castration-Resistant - genetics</topic><topic>Prostatic Neoplasms, Castration-Resistant - metabolism</topic><topic>Prostatic Neoplasms, Castration-Resistant - pathology</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA Interference</topic><topic>STAT6</topic><topic>STAT6 Transcription Factor - genetics</topic><topic>STAT6 Transcription Factor - metabolism</topic><topic>TRANSCRIPTION</topic><topic>TRANSDUCERS</topic><topic>Tumor Suppressor Proteins - genetics</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Dachuang</creatorcontrib><creatorcontrib>Tao, Tao</creatorcontrib><creatorcontrib>Xu, Bin</creatorcontrib><creatorcontrib>Chen, Shuqiu</creatorcontrib><creatorcontrib>Liu, Chunhui</creatorcontrib><creatorcontrib>Zhang, Lei</creatorcontrib><creatorcontrib>Lu, Kai</creatorcontrib><creatorcontrib>Huang, Yeqing</creatorcontrib><creatorcontrib>Jiang, Liang</creatorcontrib><creatorcontrib>Zhang, Xiaowen</creatorcontrib><creatorcontrib>Huang, Xiaoming</creatorcontrib><creatorcontrib>Zhang, Lihua</creatorcontrib><creatorcontrib>Han, Conghui</creatorcontrib><creatorcontrib>Chen, Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Dachuang</au><au>Tao, Tao</au><au>Xu, Bin</au><au>Chen, Shuqiu</au><au>Liu, Chunhui</au><au>Zhang, Lei</au><au>Lu, Kai</au><au>Huang, Yeqing</au><au>Jiang, Liang</au><au>Zhang, Xiaowen</au><au>Huang, Xiaoming</au><au>Zhang, Lihua</au><au>Han, Conghui</au><au>Chen, Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6)</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>2014-02-28</date><risdate>2014</risdate><volume>445</volume><issue>1</issue><spage>151</spage><epage>156</epage><pages>151-156</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>•The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date.•We found that the expression of miR-361-5p in CRPC was lower than in ADPC.•MiR-361-5p suppressed DU145 cell proliferation and triggered apoptosis.•STAT6 is a direct target of miR-361-5p.•STAT6 enhances the expression of Bcl-xL at the transcriptional level.
Castration-resistant prostate cancer (CRPC), whose pathogenesis is known to be regulated by microRNAs (miRNAs), has a poor prognosis. In our present study, we found that the expression of miR-361-5p in CRPC was lower than in androgen-dependent prostate cancer (ADPC), indicating that miR-361-5p may play an important role in the progression of ADPC to CRPC. The role of miR-361-5p in prostate cancer (PCa) has not been evaluated until date. Our findings suggest that miR-361-5p is a suppressor in CRPC. Signal transducer and activator of transcription-6 (STAT6), a direct target of miR-361-5p, enhances the expression of B-cell lymphoma-extra large (Bcl-xL), while miR-361-5p inhibits its expression through STAT6. Therefore, miR-361-5p has great clinical significance in preventing the malignant progression of PCa.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24491557</pmid><doi>10.1016/j.bbrc.2014.01.140</doi><tpages>6</tpages></addata></record> |
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| subjects | 3' Untranslated Regions - genetics 60 APPLIED LIFE SCIENCES ANDROGENS Animals APOPTOSIS bcl-X Protein - genetics bcl-X Protein - metabolism Bcl-xL Blotting, Western BORON CHLORIDES CASTRATION Castration-resistant prostate cancer (CRPC) Cell Line, Tumor CELL PROLIFERATION Gene Expression Profiling Gene Expression Regulation, Neoplastic Humans LYMPHOMAS Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics miR-361-5p Mutation Oligonucleotide Array Sequence Analysis PATHOGENESIS PROSTATE Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Prostatic Neoplasms, Castration-Resistant - genetics Prostatic Neoplasms, Castration-Resistant - metabolism Prostatic Neoplasms, Castration-Resistant - pathology Reverse Transcriptase Polymerase Chain Reaction RNA Interference STAT6 STAT6 Transcription Factor - genetics STAT6 Transcription Factor - metabolism TRANSCRIPTION TRANSDUCERS Tumor Suppressor Proteins - genetics Xenograft Model Antitumor Assays |
| title | MiR-361-5p acts as a tumor suppressor in prostate cancer by targeting signal transducer and activator of transcription-6(STAT6) |
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