Feasibility of RACT for 3D dose measurement and range verification in a water phantom
Purpose: The objective of this study is to establish the feasibility of using radiation‐induced acoustics to measure the range and Bragg peak dose from a pulsed proton beam. Simulation studies implementing a prototype scanner design based on computed tomographic methods were performed to investigate...
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| Veröffentlicht in: | Medical physics (Lancaster) 2015-02, Vol.42 (2), p.937-946 |
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| creator | Alsanea, Fahed Moskvin, Vadim Stantz, Keith M. |
| description | Purpose:
The objective of this study is to establish the feasibility of using radiation‐induced acoustics to measure the range and Bragg peak dose from a pulsed proton beam. Simulation studies implementing a prototype scanner design based on computed tomographic methods were performed to investigate the sensitivity to proton range and integral dose.
Methods:
Derived from thermodynamic wave equation, the pressure signals generated from the dose deposited from a pulsed proton beam with a 1 cm lateral beam width and a range of 16, 20, and 27 cm in water using Monte Carlo methods were simulated. The resulting dosimetric images were reconstructed implementing a 3D filtered backprojection algorithm and the pressure signals acquired from a 71‐transducer array with a cylindrical geometry (30 × 40 cm) rotated over 2π about its central axis. Dependencies on the detector bandwidth and proton beam pulse width were performed, after which, different noise levels were added to the detector signals (using 1 μs pulse width and a 0.5 MHz cutoff frequency/hydrophone) to investigate the statistical and systematic errors in the proton range (at 20 cm) and Bragg peak dose (of 1 cGy).
Results:
The reconstructed radioacoustic computed tomographic image intensity was shown to be linearly correlated to the dose within the Bragg peak. And, based on noise dependent studies, a detector sensitivity of 38 mPa was necessary to determine the proton range to within 1.0 mm (full‐width at half‐maximum) (systematic error < 150 μm) for a 1 cGy Bragg peak dose, where the integral dose within the Bragg peak was measured to within 2%. For existing hydrophone detector sensitivities, a Bragg peak dose of 1.6 cGy is possible.
Conclusions:
This study demonstrates that computed tomographic scanner based on ionizing radiation‐induced acoustics can be used to verify dose distribution and proton range with centi‐Gray sensitivity. Realizing this technology into the clinic has the potential to significantly impact beam commissioning, treatment verification during particle beam therapy and image guided techniques. |
| doi_str_mv | 10.1118/1.4906241 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22413455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1652456792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4521-3d09cc956daf87aba3b5df17bbe788c9ea8971bff419a4f29a5c91b931f138273</originalsourceid><addsrcrecordid>eNp10E9P2zAYx3ELDUHpOOwNIEu7jEOK_ybxEXWwTQIxTexsOc7j1Sixi-1S9d0vo2U3Tj74o98jfRH6RMmCUtpe0YVQpGaCHqEZEw2vBCPqA5oRokTFBJGn6CznJ0JIzSU5QadM1pJJUs_Q71sw2Xd-8GWHo8O_rpeP2MWE-Vfcxwx4nP43CUYIBZvQ42TCH8AvkLzz1hQfA_YBG7w1BRJer0wocfyIjp0ZMpwf3vl05-Zx-b26e_j2Y3l9V1khGa14T5S1Sta9cW1jOsM72TvadB00bWsVmFY1tHNOUGWEY8pIq2inOHWUt6zhc_R5vxtz8TpbX8CubAwBbNFsCsKFlJP6slfrFJ83kIsefbYwDCZA3GRNpxhC1o1iE73cU5tizgmcXic_mrTTlOh_rTXVh9aTvTjMbroR-v_yLe4Eqj3Y-gF27y_p-5-vg38BMv6Eug</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1652456792</pqid></control><display><type>article</type><title>Feasibility of RACT for 3D dose measurement and range verification in a water phantom</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Alsanea, Fahed ; Moskvin, Vadim ; Stantz, Keith M.</creator><creatorcontrib>Alsanea, Fahed ; Moskvin, Vadim ; Stantz, Keith M.</creatorcontrib><description>Purpose:
The objective of this study is to establish the feasibility of using radiation‐induced acoustics to measure the range and Bragg peak dose from a pulsed proton beam. Simulation studies implementing a prototype scanner design based on computed tomographic methods were performed to investigate the sensitivity to proton range and integral dose.
Methods:
Derived from thermodynamic wave equation, the pressure signals generated from the dose deposited from a pulsed proton beam with a 1 cm lateral beam width and a range of 16, 20, and 27 cm in water using Monte Carlo methods were simulated. The resulting dosimetric images were reconstructed implementing a 3D filtered backprojection algorithm and the pressure signals acquired from a 71‐transducer array with a cylindrical geometry (30 × 40 cm) rotated over 2π about its central axis. Dependencies on the detector bandwidth and proton beam pulse width were performed, after which, different noise levels were added to the detector signals (using 1 μs pulse width and a 0.5 MHz cutoff frequency/hydrophone) to investigate the statistical and systematic errors in the proton range (at 20 cm) and Bragg peak dose (of 1 cGy).
Results:
The reconstructed radioacoustic computed tomographic image intensity was shown to be linearly correlated to the dose within the Bragg peak. And, based on noise dependent studies, a detector sensitivity of 38 mPa was necessary to determine the proton range to within 1.0 mm (full‐width at half‐maximum) (systematic error < 150 μm) for a 1 cGy Bragg peak dose, where the integral dose within the Bragg peak was measured to within 2%. For existing hydrophone detector sensitivities, a Bragg peak dose of 1.6 cGy is possible.
Conclusions:
This study demonstrates that computed tomographic scanner based on ionizing radiation‐induced acoustics can be used to verify dose distribution and proton range with centi‐Gray sensitivity. Realizing this technology into the clinic has the potential to significantly impact beam commissioning, treatment verification during particle beam therapy and image guided techniques.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4906241</identifier><identifier>PMID: 25652506</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>07 ISOTOPES AND RADIATION SOURCES ; acoustic tomography ; Acoustics ; BEAM PROFILES ; Biological material, e.g. blood, urine; Haemocytometers ; biomedical ultrasonics ; BRAGG CURVE ; COMMISSIONING ; Computed tomography ; Computerised tomographs ; computerised tomography ; Diagnosis using ultrasonic, sonic or infrasonic waves ; Digital computing or data processing equipment or methods, specially adapted for specific applications ; dosimetry ; Dosimetry/exposure assessment ; Feasibility Studies ; hydrophones ; Image data processing or generation, in general ; image reconstruction ; Image scanners ; Image sensors ; Imaging, Three-Dimensional - instrumentation ; INTEGRAL DOSES ; measurement errors ; medical image processing ; Medical imaging ; Microphones ; Monte Carlo Method ; Monte Carlo methods ; Monte Carlo simulations ; PHANTOMS ; Phantoms, Imaging ; Pressure ; PROTON BEAMS ; proton dosimetry ; Protons ; Radiation Dosage ; RADIATION DOSE DISTRIBUTIONS ; radiation therapy ; Radiography - instrumentation ; Radiometry - instrumentation ; RADIOTHERAPY ; range verification ; Reconstruction ; Scintigraphy ; Special adaptations for subaqueous use, e.g. for hydrophone ; statistical analysis ; Therapeutic applications, including brachytherapy ; thermoacoustic imaging ; Three dimensional image processing ; Ultrasonographic imaging ; Water ; wave equations</subject><ispartof>Medical physics (Lancaster), 2015-02, Vol.42 (2), p.937-946</ispartof><rights>2015 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4521-3d09cc956daf87aba3b5df17bbe788c9ea8971bff419a4f29a5c91b931f138273</citedby><cites>FETCH-LOGICAL-c4521-3d09cc956daf87aba3b5df17bbe788c9ea8971bff419a4f29a5c91b931f138273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4906241$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4906241$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25652506$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22413455$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Alsanea, Fahed</creatorcontrib><creatorcontrib>Moskvin, Vadim</creatorcontrib><creatorcontrib>Stantz, Keith M.</creatorcontrib><title>Feasibility of RACT for 3D dose measurement and range verification in a water phantom</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
The objective of this study is to establish the feasibility of using radiation‐induced acoustics to measure the range and Bragg peak dose from a pulsed proton beam. Simulation studies implementing a prototype scanner design based on computed tomographic methods were performed to investigate the sensitivity to proton range and integral dose.
Methods:
Derived from thermodynamic wave equation, the pressure signals generated from the dose deposited from a pulsed proton beam with a 1 cm lateral beam width and a range of 16, 20, and 27 cm in water using Monte Carlo methods were simulated. The resulting dosimetric images were reconstructed implementing a 3D filtered backprojection algorithm and the pressure signals acquired from a 71‐transducer array with a cylindrical geometry (30 × 40 cm) rotated over 2π about its central axis. Dependencies on the detector bandwidth and proton beam pulse width were performed, after which, different noise levels were added to the detector signals (using 1 μs pulse width and a 0.5 MHz cutoff frequency/hydrophone) to investigate the statistical and systematic errors in the proton range (at 20 cm) and Bragg peak dose (of 1 cGy).
Results:
The reconstructed radioacoustic computed tomographic image intensity was shown to be linearly correlated to the dose within the Bragg peak. And, based on noise dependent studies, a detector sensitivity of 38 mPa was necessary to determine the proton range to within 1.0 mm (full‐width at half‐maximum) (systematic error < 150 μm) for a 1 cGy Bragg peak dose, where the integral dose within the Bragg peak was measured to within 2%. For existing hydrophone detector sensitivities, a Bragg peak dose of 1.6 cGy is possible.
Conclusions:
This study demonstrates that computed tomographic scanner based on ionizing radiation‐induced acoustics can be used to verify dose distribution and proton range with centi‐Gray sensitivity. Realizing this technology into the clinic has the potential to significantly impact beam commissioning, treatment verification during particle beam therapy and image guided techniques.</description><subject>07 ISOTOPES AND RADIATION SOURCES</subject><subject>acoustic tomography</subject><subject>Acoustics</subject><subject>BEAM PROFILES</subject><subject>Biological material, e.g. blood, urine; Haemocytometers</subject><subject>biomedical ultrasonics</subject><subject>BRAGG CURVE</subject><subject>COMMISSIONING</subject><subject>Computed tomography</subject><subject>Computerised tomographs</subject><subject>computerised tomography</subject><subject>Diagnosis using ultrasonic, sonic or infrasonic waves</subject><subject>Digital computing or data processing equipment or methods, specially adapted for specific applications</subject><subject>dosimetry</subject><subject>Dosimetry/exposure assessment</subject><subject>Feasibility Studies</subject><subject>hydrophones</subject><subject>Image data processing or generation, in general</subject><subject>image reconstruction</subject><subject>Image scanners</subject><subject>Image sensors</subject><subject>Imaging, Three-Dimensional - instrumentation</subject><subject>INTEGRAL DOSES</subject><subject>measurement errors</subject><subject>medical image processing</subject><subject>Medical imaging</subject><subject>Microphones</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo methods</subject><subject>Monte Carlo simulations</subject><subject>PHANTOMS</subject><subject>Phantoms, Imaging</subject><subject>Pressure</subject><subject>PROTON BEAMS</subject><subject>proton dosimetry</subject><subject>Protons</subject><subject>Radiation Dosage</subject><subject>RADIATION DOSE DISTRIBUTIONS</subject><subject>radiation therapy</subject><subject>Radiography - instrumentation</subject><subject>Radiometry - instrumentation</subject><subject>RADIOTHERAPY</subject><subject>range verification</subject><subject>Reconstruction</subject><subject>Scintigraphy</subject><subject>Special adaptations for subaqueous use, e.g. for hydrophone</subject><subject>statistical analysis</subject><subject>Therapeutic applications, including brachytherapy</subject><subject>thermoacoustic imaging</subject><subject>Three dimensional image processing</subject><subject>Ultrasonographic imaging</subject><subject>Water</subject><subject>wave equations</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9P2zAYx3ELDUHpOOwNIEu7jEOK_ybxEXWwTQIxTexsOc7j1Sixi-1S9d0vo2U3Tj74o98jfRH6RMmCUtpe0YVQpGaCHqEZEw2vBCPqA5oRokTFBJGn6CznJ0JIzSU5QadM1pJJUs_Q71sw2Xd-8GWHo8O_rpeP2MWE-Vfcxwx4nP43CUYIBZvQ42TCH8AvkLzz1hQfA_YBG7w1BRJer0wocfyIjp0ZMpwf3vl05-Zx-b26e_j2Y3l9V1khGa14T5S1Sta9cW1jOsM72TvadB00bWsVmFY1tHNOUGWEY8pIq2inOHWUt6zhc_R5vxtz8TpbX8CubAwBbNFsCsKFlJP6slfrFJ83kIsefbYwDCZA3GRNpxhC1o1iE73cU5tizgmcXic_mrTTlOh_rTXVh9aTvTjMbroR-v_yLe4Eqj3Y-gF27y_p-5-vg38BMv6Eug</recordid><startdate>201502</startdate><enddate>201502</enddate><creator>Alsanea, Fahed</creator><creator>Moskvin, Vadim</creator><creator>Stantz, Keith M.</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>201502</creationdate><title>Feasibility of RACT for 3D dose measurement and range verification in a water phantom</title><author>Alsanea, Fahed ; Moskvin, Vadim ; Stantz, Keith M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4521-3d09cc956daf87aba3b5df17bbe788c9ea8971bff419a4f29a5c91b931f138273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>07 ISOTOPES AND RADIATION SOURCES</topic><topic>acoustic tomography</topic><topic>Acoustics</topic><topic>BEAM PROFILES</topic><topic>Biological material, e.g. blood, urine; Haemocytometers</topic><topic>biomedical ultrasonics</topic><topic>BRAGG CURVE</topic><topic>COMMISSIONING</topic><topic>Computed tomography</topic><topic>Computerised tomographs</topic><topic>computerised tomography</topic><topic>Diagnosis using ultrasonic, sonic or infrasonic waves</topic><topic>Digital computing or data processing equipment or methods, specially adapted for specific applications</topic><topic>dosimetry</topic><topic>Dosimetry/exposure assessment</topic><topic>Feasibility Studies</topic><topic>hydrophones</topic><topic>Image data processing or generation, in general</topic><topic>image reconstruction</topic><topic>Image scanners</topic><topic>Image sensors</topic><topic>Imaging, Three-Dimensional - instrumentation</topic><topic>INTEGRAL DOSES</topic><topic>measurement errors</topic><topic>medical image processing</topic><topic>Medical imaging</topic><topic>Microphones</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo methods</topic><topic>Monte Carlo simulations</topic><topic>PHANTOMS</topic><topic>Phantoms, Imaging</topic><topic>Pressure</topic><topic>PROTON BEAMS</topic><topic>proton dosimetry</topic><topic>Protons</topic><topic>Radiation Dosage</topic><topic>RADIATION DOSE DISTRIBUTIONS</topic><topic>radiation therapy</topic><topic>Radiography - instrumentation</topic><topic>Radiometry - instrumentation</topic><topic>RADIOTHERAPY</topic><topic>range verification</topic><topic>Reconstruction</topic><topic>Scintigraphy</topic><topic>Special adaptations for subaqueous use, e.g. for hydrophone</topic><topic>statistical analysis</topic><topic>Therapeutic applications, including brachytherapy</topic><topic>thermoacoustic imaging</topic><topic>Three dimensional image processing</topic><topic>Ultrasonographic imaging</topic><topic>Water</topic><topic>wave equations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alsanea, Fahed</creatorcontrib><creatorcontrib>Moskvin, Vadim</creatorcontrib><creatorcontrib>Stantz, Keith M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alsanea, Fahed</au><au>Moskvin, Vadim</au><au>Stantz, Keith M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feasibility of RACT for 3D dose measurement and range verification in a water phantom</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2015-02</date><risdate>2015</risdate><volume>42</volume><issue>2</issue><spage>937</spage><epage>946</epage><pages>937-946</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><abstract>Purpose:
The objective of this study is to establish the feasibility of using radiation‐induced acoustics to measure the range and Bragg peak dose from a pulsed proton beam. Simulation studies implementing a prototype scanner design based on computed tomographic methods were performed to investigate the sensitivity to proton range and integral dose.
Methods:
Derived from thermodynamic wave equation, the pressure signals generated from the dose deposited from a pulsed proton beam with a 1 cm lateral beam width and a range of 16, 20, and 27 cm in water using Monte Carlo methods were simulated. The resulting dosimetric images were reconstructed implementing a 3D filtered backprojection algorithm and the pressure signals acquired from a 71‐transducer array with a cylindrical geometry (30 × 40 cm) rotated over 2π about its central axis. Dependencies on the detector bandwidth and proton beam pulse width were performed, after which, different noise levels were added to the detector signals (using 1 μs pulse width and a 0.5 MHz cutoff frequency/hydrophone) to investigate the statistical and systematic errors in the proton range (at 20 cm) and Bragg peak dose (of 1 cGy).
Results:
The reconstructed radioacoustic computed tomographic image intensity was shown to be linearly correlated to the dose within the Bragg peak. And, based on noise dependent studies, a detector sensitivity of 38 mPa was necessary to determine the proton range to within 1.0 mm (full‐width at half‐maximum) (systematic error < 150 μm) for a 1 cGy Bragg peak dose, where the integral dose within the Bragg peak was measured to within 2%. For existing hydrophone detector sensitivities, a Bragg peak dose of 1.6 cGy is possible.
Conclusions:
This study demonstrates that computed tomographic scanner based on ionizing radiation‐induced acoustics can be used to verify dose distribution and proton range with centi‐Gray sensitivity. Realizing this technology into the clinic has the potential to significantly impact beam commissioning, treatment verification during particle beam therapy and image guided techniques.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>25652506</pmid><doi>10.1118/1.4906241</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Medical physics (Lancaster), 2015-02, Vol.42 (2), p.937-946 |
| issn | 0094-2405 2473-4209 |
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| recordid | cdi_osti_scitechconnect_22413455 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | 07 ISOTOPES AND RADIATION SOURCES acoustic tomography Acoustics BEAM PROFILES Biological material, e.g. blood, urine Haemocytometers biomedical ultrasonics BRAGG CURVE COMMISSIONING Computed tomography Computerised tomographs computerised tomography Diagnosis using ultrasonic, sonic or infrasonic waves Digital computing or data processing equipment or methods, specially adapted for specific applications dosimetry Dosimetry/exposure assessment Feasibility Studies hydrophones Image data processing or generation, in general image reconstruction Image scanners Image sensors Imaging, Three-Dimensional - instrumentation INTEGRAL DOSES measurement errors medical image processing Medical imaging Microphones Monte Carlo Method Monte Carlo methods Monte Carlo simulations PHANTOMS Phantoms, Imaging Pressure PROTON BEAMS proton dosimetry Protons Radiation Dosage RADIATION DOSE DISTRIBUTIONS radiation therapy Radiography - instrumentation Radiometry - instrumentation RADIOTHERAPY range verification Reconstruction Scintigraphy Special adaptations for subaqueous use, e.g. for hydrophone statistical analysis Therapeutic applications, including brachytherapy thermoacoustic imaging Three dimensional image processing Ultrasonographic imaging Water wave equations |
| title | Feasibility of RACT for 3D dose measurement and range verification in a water phantom |
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