Reproducibility of quantitative measures of binding potential in rat striatum: A test re-test study using DTBZ dynamic PET studies
There is great interest in the study of dopamine (DA) pathways due to the increasing number of patients with illnesses related to the dopaminergic system and molecular imaging based in Positron Emission Tomography (PET) has been proven helpful for this task. Among the different radiopharmaceuticals...
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| creator | Avendaño-Estrada, A Lara-Camacho, V M Ávila-García, M C Ávila- Rodríguez M A |
| description | There is great interest in the study of dopamine (DA) pathways due to the increasing number of patients with illnesses related to the dopaminergic system and molecular imaging based in Positron Emission Tomography (PET) has been proven helpful for this task. Among the different radiopharmaceuticals available to study DA interaction, [11C]Dihydrotetrabenazine (DTBZ) has a high affinity for the vesicular monoamine transporter type 2 (VMAT2) and its binding potential (BP) is a marker of DA terminal integrity. This paper reports on the intersubject reproducibility of BP measurements in rat striatum with [11C]DTBZ using the Logańs method. |
| doi_str_mv | 10.1063/1.4901371 |
| format | Conference Proceeding |
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Among the different radiopharmaceuticals available to study DA interaction, [11C]Dihydrotetrabenazine (DTBZ) has a high affinity for the vesicular monoamine transporter type 2 (VMAT2) and its binding potential (BP) is a marker of DA terminal integrity. This paper reports on the intersubject reproducibility of BP measurements in rat striatum with [11C]DTBZ using the Logańs method.</description><identifier>ISSN: 0094-243X</identifier><identifier>EISSN: 1551-7616</identifier><identifier>DOI: 10.1063/1.4901371</identifier><language>eng</language><publisher>Melville: American Institute of Physics</publisher><subject>Binding ; BORON PHOSPHIDES ; CARBON 11 ; DOPAMINE ; Illnesses ; LIPOSOMES ; NERVOUS SYSTEM DISEASES ; PATIENTS ; POSITRON COMPUTED TOMOGRAPHY ; Positron emission ; RADIOLOGY AND NUCLEAR MEDICINE ; RADIOPHARMACEUTICALS ; RATS ; Reproducibility ; Tomography</subject><ispartof>AIP conference proceedings, 2014, Vol.1626 (1), p.113</ispartof><rights>2014 AIP Publishing LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,309,310,314,776,780,785,786,881,23909,23910,25118,27901,27902</link.rule.ids><backlink>$$Uhttps://www.osti.gov/biblio/22390507$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Avendaño-Estrada, A</creatorcontrib><creatorcontrib>Lara-Camacho, V M</creatorcontrib><creatorcontrib>Ávila-García, M C</creatorcontrib><creatorcontrib>Ávila- Rodríguez M A</creatorcontrib><title>Reproducibility of quantitative measures of binding potential in rat striatum: A test re-test study using DTBZ dynamic PET studies</title><title>AIP conference proceedings</title><description>There is great interest in the study of dopamine (DA) pathways due to the increasing number of patients with illnesses related to the dopaminergic system and molecular imaging based in Positron Emission Tomography (PET) has been proven helpful for this task. Among the different radiopharmaceuticals available to study DA interaction, [11C]Dihydrotetrabenazine (DTBZ) has a high affinity for the vesicular monoamine transporter type 2 (VMAT2) and its binding potential (BP) is a marker of DA terminal integrity. This paper reports on the intersubject reproducibility of BP measurements in rat striatum with [11C]DTBZ using the Logańs method.</description><subject>Binding</subject><subject>BORON PHOSPHIDES</subject><subject>CARBON 11</subject><subject>DOPAMINE</subject><subject>Illnesses</subject><subject>LIPOSOMES</subject><subject>NERVOUS SYSTEM DISEASES</subject><subject>PATIENTS</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Positron emission</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>RADIOPHARMACEUTICALS</subject><subject>RATS</subject><subject>Reproducibility</subject><subject>Tomography</subject><issn>0094-243X</issn><issn>1551-7616</issn><fulltext>true</fulltext><rsrctype>conference_proceeding</rsrctype><creationdate>2014</creationdate><recordtype>conference_proceeding</recordtype><recordid>eNpFUEtLAzEYDKJgrR78BwHPq_ny3HirtT6goEgF8bKk2URT2t12kwi9-svdVsHTHObBzCB0DuQSiGRXcMk1AabgAA1ACCiUBHmIBoRoXlDO3o7RSYwLQqhWqhyg7xe37to62zAPy5C2uPV4k02TQjIpfDm8cibmzsUdMQ9NHZoPvG6T6xVmiUODO5NwTF0wKa-u8QgnFxPuXLHHmHK9xTnuXLezm3dcbxuzChY_T2Z7Mrh4io68WUZ39odD9Ho3mY0fiunT_eN4NC1aCpAKDkT4uQFRak8F8aWw0iirSsmlZEq7WhKva-mot4SB5KI0ytBae8U4cM2G6OI3t40pVNGG5OynbZvG2VRRyjQRRP2r-ls2ud9QLdrcNX2xigKVAoguGfsBlBhtRw</recordid><startdate>20141107</startdate><enddate>20141107</enddate><creator>Avendaño-Estrada, A</creator><creator>Lara-Camacho, V M</creator><creator>Ávila-García, M C</creator><creator>Ávila- Rodríguez M A</creator><general>American Institute of Physics</general><scope>8FD</scope><scope>H8D</scope><scope>L7M</scope><scope>OTOTI</scope></search><sort><creationdate>20141107</creationdate><title>Reproducibility of quantitative measures of binding potential in rat striatum: A test re-test study using DTBZ dynamic PET studies</title><author>Avendaño-Estrada, A ; Lara-Camacho, V M ; Ávila-García, M C ; Ávila- Rodríguez M A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-o211t-4105fba1589f250f85c6a7c786466379ed60f9d6e2fc0316458a7a2d9f7341493</frbrgroupid><rsrctype>conference_proceedings</rsrctype><prefilter>conference_proceedings</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Binding</topic><topic>BORON PHOSPHIDES</topic><topic>CARBON 11</topic><topic>DOPAMINE</topic><topic>Illnesses</topic><topic>LIPOSOMES</topic><topic>NERVOUS SYSTEM DISEASES</topic><topic>PATIENTS</topic><topic>POSITRON COMPUTED TOMOGRAPHY</topic><topic>Positron emission</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>RADIOPHARMACEUTICALS</topic><topic>RATS</topic><topic>Reproducibility</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Avendaño-Estrada, A</creatorcontrib><creatorcontrib>Lara-Camacho, V M</creatorcontrib><creatorcontrib>Ávila-García, M C</creatorcontrib><creatorcontrib>Ávila- Rodríguez M A</creatorcontrib><collection>Technology Research Database</collection><collection>Aerospace Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>OSTI.GOV</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Avendaño-Estrada, A</au><au>Lara-Camacho, V M</au><au>Ávila-García, M C</au><au>Ávila- Rodríguez M A</au><format>book</format><genre>proceeding</genre><ristype>CONF</ristype><atitle>Reproducibility of quantitative measures of binding potential in rat striatum: A test re-test study using DTBZ dynamic PET studies</atitle><btitle>AIP conference proceedings</btitle><date>2014-11-07</date><risdate>2014</risdate><volume>1626</volume><issue>1</issue><epage>113</epage><issn>0094-243X</issn><eissn>1551-7616</eissn><abstract>There is great interest in the study of dopamine (DA) pathways due to the increasing number of patients with illnesses related to the dopaminergic system and molecular imaging based in Positron Emission Tomography (PET) has been proven helpful for this task. 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| fulltext | fulltext |
| identifier | ISSN: 0094-243X |
| ispartof | AIP conference proceedings, 2014, Vol.1626 (1), p.113 |
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| language | eng |
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| source | AIP Journals Complete |
| subjects | Binding BORON PHOSPHIDES CARBON 11 DOPAMINE Illnesses LIPOSOMES NERVOUS SYSTEM DISEASES PATIENTS POSITRON COMPUTED TOMOGRAPHY Positron emission RADIOLOGY AND NUCLEAR MEDICINE RADIOPHARMACEUTICALS RATS Reproducibility Tomography |
| title | Reproducibility of quantitative measures of binding potential in rat striatum: A test re-test study using DTBZ dynamic PET studies |
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