High resolution Cerenkov light imaging of induced positron distribution in proton therapy
Purpose: In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenk...
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| creator | Yamamoto, Seiichi Toshito, Toshiyuki Fujii, Kento Morishita, Yuki Okumura, Satoshi Komori, Masataka |
| description | Purpose:
In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenkov light imaging is a new molecular imaging technology that detects the visible photons that are produced from high‐speed electrons using a high sensitivity optical camera. Because its inherent spatial resolution is much higher than PET, the authors can measure more precise information of the proton‐induced positron distribution with Cerenkov light imaging technology. For this purpose, they conducted Cerenkov light imaging of induced positron distribution in proton therapy.
Methods:
First, the authors evaluated the spatial resolution of our Cerenkov light imaging system with a 22Na point source for the actual imaging setup. Then the transparent acrylic phantoms (100 × 100 × 100 mm3) were irradiated with two different proton energies using a spot scanning proton therapy system. Cerenkov light imaging of each phantom was conducted using a high sensitivity electron multiplied charge coupled device (EM‐CCD) camera.
Results:
The Cerenkov light's spatial resolution for the setup was 0.76 ± 0.6 mm FWHM. They obtained high resolution Cerenkov light images of the positron distributions in the phantoms for two different proton energies and made fused images of the reference images and the Cerenkov light images. The depths of the positron distribution in the phantoms from the Cerenkov light images were almost identical to the simulation results. The decay curves derived from the region‐of‐interests (ROIs) set on the Cerenkov light images revealed that Cerenkov light images can be used for estimating the half‐life of the radionuclide components of positrons.
Conclusions:
High resolution Cerenkov light imaging of proton‐induced positron distribution was possible. The authors conclude that Cerenkov light imaging of proton‐induced positron is promising for proton therapy. |
| doi_str_mv | 10.1118/1.4898592 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_osti_</sourceid><recordid>TN_cdi_osti_scitechconnect_22320351</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1621214872</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4172-2c604fb6a968124050efd47b58046db313ddb811d7940e4922c9378b0dc8b6953</originalsourceid><addsrcrecordid>eNp10E9P2zAYBnALDdHSceALTJF2GYew13_i2MepGnQSCA5w2MlKbKf1SOPOdkD99nOXsttOr6X350evHoQuMVxjjMVXfM2EFJUkJ2hOWE1LRkB-QHMAyUrCoJqh8xh_AQCnFZyhGaloDZzxOfq5cutNEWz0_ZicH4qlDXZ48a9FnxepcNtm7YZ14bvCDWbU1hQ7H10KmRoXU3Dt9M8NxS74lF9pY0Oz239Ep13TR3txnAv0fPP9abkq7x5ufyy_3ZWa4ZqURHNgXcsbyQU-3Aq2M6xuKwGMm5ZiakwrMDa1ZGCZJERLWosWjBYtlxVdoM9Tro_Jqahdsnqj_TBYnRQhlACtcFZfJpWP_D3amNTWRW37vhmsH6PCnGCCmahJplcT1cHHGGyndiHXEPYKgzr0rbA69p3tp2Ps2G6t-SffC86gnMCb6-3-_0nq_vFv4B8y5Yb_</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1621214872</pqid></control><display><type>article</type><title>High resolution Cerenkov light imaging of induced positron distribution in proton therapy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Yamamoto, Seiichi ; Toshito, Toshiyuki ; Fujii, Kento ; Morishita, Yuki ; Okumura, Satoshi ; Komori, Masataka</creator><creatorcontrib>Yamamoto, Seiichi ; Toshito, Toshiyuki ; Fujii, Kento ; Morishita, Yuki ; Okumura, Satoshi ; Komori, Masataka</creatorcontrib><description>Purpose:
In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenkov light imaging is a new molecular imaging technology that detects the visible photons that are produced from high‐speed electrons using a high sensitivity optical camera. Because its inherent spatial resolution is much higher than PET, the authors can measure more precise information of the proton‐induced positron distribution with Cerenkov light imaging technology. For this purpose, they conducted Cerenkov light imaging of induced positron distribution in proton therapy.
Methods:
First, the authors evaluated the spatial resolution of our Cerenkov light imaging system with a 22Na point source for the actual imaging setup. Then the transparent acrylic phantoms (100 × 100 × 100 mm3) were irradiated with two different proton energies using a spot scanning proton therapy system. Cerenkov light imaging of each phantom was conducted using a high sensitivity electron multiplied charge coupled device (EM‐CCD) camera.
Results:
The Cerenkov light's spatial resolution for the setup was 0.76 ± 0.6 mm FWHM. They obtained high resolution Cerenkov light images of the positron distributions in the phantoms for two different proton energies and made fused images of the reference images and the Cerenkov light images. The depths of the positron distribution in the phantoms from the Cerenkov light images were almost identical to the simulation results. The decay curves derived from the region‐of‐interests (ROIs) set on the Cerenkov light images revealed that Cerenkov light images can be used for estimating the half‐life of the radionuclide components of positrons.
Conclusions:
High resolution Cerenkov light imaging of proton‐induced positron distribution was possible. The authors conclude that Cerenkov light imaging of proton‐induced positron is promising for proton therapy.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4898592</identifier><identifier>PMID: 25370646</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>60 APPLIED LIFE SCIENCES ; Biological material, e.g. blood, urine; Haemocytometers ; biomedical optical imaging ; cameras ; CCD camera ; Cerenkov light imaging ; CHARGE-COUPLED DEVICES ; DECAY ; Details of cameras or camera bodies; Accessories therefor ; DIAGRAMS ; Digital computing or data processing equipment or methods, specially adapted for specific applications ; DISTRIBUTION ; ELECTRONS ; HALF-LIFE ; high spatial resolution ; Image data processing or generation, in general ; image fusion ; image resolution ; INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY ; IRRADIATION ; Light ; medical image processing ; Medical image spatial resolution ; Monte Carlo Method ; Monte Carlo methods ; Optical Imaging ; PHANTOMS ; Phantoms, Imaging ; PHOTONS ; POINT SOURCES ; positron ; POSITRON COMPUTED TOMOGRAPHY ; Positron emission tomography ; POSITRONS ; proton therapy ; Proton Therapy - methods ; PROTONS ; radiation therapy ; radioisotopes ; SENSITIVITY ; SIMULATION ; Sodium ; SODIUM 22 ; SPATIAL RESOLUTION ; Therapeutic applications ; Therapeutic applications, including brachytherapy ; THERAPY ; Thermography ; VELOCITY</subject><ispartof>Medical physics (Lancaster), 2014-11, Vol.41 (11), p.111913-n/a</ispartof><rights>2014 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4172-2c604fb6a968124050efd47b58046db313ddb811d7940e4922c9378b0dc8b6953</citedby><cites>FETCH-LOGICAL-c4172-2c604fb6a968124050efd47b58046db313ddb811d7940e4922c9378b0dc8b6953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4898592$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4898592$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25370646$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/22320351$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamamoto, Seiichi</creatorcontrib><creatorcontrib>Toshito, Toshiyuki</creatorcontrib><creatorcontrib>Fujii, Kento</creatorcontrib><creatorcontrib>Morishita, Yuki</creatorcontrib><creatorcontrib>Okumura, Satoshi</creatorcontrib><creatorcontrib>Komori, Masataka</creatorcontrib><title>High resolution Cerenkov light imaging of induced positron distribution in proton therapy</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenkov light imaging is a new molecular imaging technology that detects the visible photons that are produced from high‐speed electrons using a high sensitivity optical camera. Because its inherent spatial resolution is much higher than PET, the authors can measure more precise information of the proton‐induced positron distribution with Cerenkov light imaging technology. For this purpose, they conducted Cerenkov light imaging of induced positron distribution in proton therapy.
Methods:
First, the authors evaluated the spatial resolution of our Cerenkov light imaging system with a 22Na point source for the actual imaging setup. Then the transparent acrylic phantoms (100 × 100 × 100 mm3) were irradiated with two different proton energies using a spot scanning proton therapy system. Cerenkov light imaging of each phantom was conducted using a high sensitivity electron multiplied charge coupled device (EM‐CCD) camera.
Results:
The Cerenkov light's spatial resolution for the setup was 0.76 ± 0.6 mm FWHM. They obtained high resolution Cerenkov light images of the positron distributions in the phantoms for two different proton energies and made fused images of the reference images and the Cerenkov light images. The depths of the positron distribution in the phantoms from the Cerenkov light images were almost identical to the simulation results. The decay curves derived from the region‐of‐interests (ROIs) set on the Cerenkov light images revealed that Cerenkov light images can be used for estimating the half‐life of the radionuclide components of positrons.
Conclusions:
High resolution Cerenkov light imaging of proton‐induced positron distribution was possible. The authors conclude that Cerenkov light imaging of proton‐induced positron is promising for proton therapy.</description><subject>60 APPLIED LIFE SCIENCES</subject><subject>Biological material, e.g. blood, urine; Haemocytometers</subject><subject>biomedical optical imaging</subject><subject>cameras</subject><subject>CCD camera</subject><subject>Cerenkov light imaging</subject><subject>CHARGE-COUPLED DEVICES</subject><subject>DECAY</subject><subject>Details of cameras or camera bodies; Accessories therefor</subject><subject>DIAGRAMS</subject><subject>Digital computing or data processing equipment or methods, specially adapted for specific applications</subject><subject>DISTRIBUTION</subject><subject>ELECTRONS</subject><subject>HALF-LIFE</subject><subject>high spatial resolution</subject><subject>Image data processing or generation, in general</subject><subject>image fusion</subject><subject>image resolution</subject><subject>INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY</subject><subject>IRRADIATION</subject><subject>Light</subject><subject>medical image processing</subject><subject>Medical image spatial resolution</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo methods</subject><subject>Optical Imaging</subject><subject>PHANTOMS</subject><subject>Phantoms, Imaging</subject><subject>PHOTONS</subject><subject>POINT SOURCES</subject><subject>positron</subject><subject>POSITRON COMPUTED TOMOGRAPHY</subject><subject>Positron emission tomography</subject><subject>POSITRONS</subject><subject>proton therapy</subject><subject>Proton Therapy - methods</subject><subject>PROTONS</subject><subject>radiation therapy</subject><subject>radioisotopes</subject><subject>SENSITIVITY</subject><subject>SIMULATION</subject><subject>Sodium</subject><subject>SODIUM 22</subject><subject>SPATIAL RESOLUTION</subject><subject>Therapeutic applications</subject><subject>Therapeutic applications, including brachytherapy</subject><subject>THERAPY</subject><subject>Thermography</subject><subject>VELOCITY</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E9P2zAYBnALDdHSceALTJF2GYew13_i2MepGnQSCA5w2MlKbKf1SOPOdkD99nOXsttOr6X350evHoQuMVxjjMVXfM2EFJUkJ2hOWE1LRkB-QHMAyUrCoJqh8xh_AQCnFZyhGaloDZzxOfq5cutNEWz0_ZicH4qlDXZ48a9FnxepcNtm7YZ14bvCDWbU1hQ7H10KmRoXU3Dt9M8NxS74lF9pY0Oz239Ep13TR3txnAv0fPP9abkq7x5ufyy_3ZWa4ZqURHNgXcsbyQU-3Aq2M6xuKwGMm5ZiakwrMDa1ZGCZJERLWosWjBYtlxVdoM9Tro_Jqahdsnqj_TBYnRQhlACtcFZfJpWP_D3amNTWRW37vhmsH6PCnGCCmahJplcT1cHHGGyndiHXEPYKgzr0rbA69p3tp2Ps2G6t-SffC86gnMCb6-3-_0nq_vFv4B8y5Yb_</recordid><startdate>201411</startdate><enddate>201411</enddate><creator>Yamamoto, Seiichi</creator><creator>Toshito, Toshiyuki</creator><creator>Fujii, Kento</creator><creator>Morishita, Yuki</creator><creator>Okumura, Satoshi</creator><creator>Komori, Masataka</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>201411</creationdate><title>High resolution Cerenkov light imaging of induced positron distribution in proton therapy</title><author>Yamamoto, Seiichi ; Toshito, Toshiyuki ; Fujii, Kento ; Morishita, Yuki ; Okumura, Satoshi ; Komori, Masataka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4172-2c604fb6a968124050efd47b58046db313ddb811d7940e4922c9378b0dc8b6953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>60 APPLIED LIFE SCIENCES</topic><topic>Biological material, e.g. blood, urine; Haemocytometers</topic><topic>biomedical optical imaging</topic><topic>cameras</topic><topic>CCD camera</topic><topic>Cerenkov light imaging</topic><topic>CHARGE-COUPLED DEVICES</topic><topic>DECAY</topic><topic>Details of cameras or camera bodies; Accessories therefor</topic><topic>DIAGRAMS</topic><topic>Digital computing or data processing equipment or methods, specially adapted for specific applications</topic><topic>DISTRIBUTION</topic><topic>ELECTRONS</topic><topic>HALF-LIFE</topic><topic>high spatial resolution</topic><topic>Image data processing or generation, in general</topic><topic>image fusion</topic><topic>image resolution</topic><topic>INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY</topic><topic>IRRADIATION</topic><topic>Light</topic><topic>medical image processing</topic><topic>Medical image spatial resolution</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo methods</topic><topic>Optical Imaging</topic><topic>PHANTOMS</topic><topic>Phantoms, Imaging</topic><topic>PHOTONS</topic><topic>POINT SOURCES</topic><topic>positron</topic><topic>POSITRON COMPUTED TOMOGRAPHY</topic><topic>Positron emission tomography</topic><topic>POSITRONS</topic><topic>proton therapy</topic><topic>Proton Therapy - methods</topic><topic>PROTONS</topic><topic>radiation therapy</topic><topic>radioisotopes</topic><topic>SENSITIVITY</topic><topic>SIMULATION</topic><topic>Sodium</topic><topic>SODIUM 22</topic><topic>SPATIAL RESOLUTION</topic><topic>Therapeutic applications</topic><topic>Therapeutic applications, including brachytherapy</topic><topic>THERAPY</topic><topic>Thermography</topic><topic>VELOCITY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamamoto, Seiichi</creatorcontrib><creatorcontrib>Toshito, Toshiyuki</creatorcontrib><creatorcontrib>Fujii, Kento</creatorcontrib><creatorcontrib>Morishita, Yuki</creatorcontrib><creatorcontrib>Okumura, Satoshi</creatorcontrib><creatorcontrib>Komori, Masataka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamamoto, Seiichi</au><au>Toshito, Toshiyuki</au><au>Fujii, Kento</au><au>Morishita, Yuki</au><au>Okumura, Satoshi</au><au>Komori, Masataka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High resolution Cerenkov light imaging of induced positron distribution in proton therapy</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2014-11</date><risdate>2014</risdate><volume>41</volume><issue>11</issue><spage>111913</spage><epage>n/a</epage><pages>111913-n/a</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><abstract>Purpose:
In proton therapy, imaging of the positron distribution produced by fragmentation during or soon after proton irradiation is a useful method to monitor the proton range. Although positron emission tomography (PET) is typically used for this imaging, its spatial resolution is limited. Cerenkov light imaging is a new molecular imaging technology that detects the visible photons that are produced from high‐speed electrons using a high sensitivity optical camera. Because its inherent spatial resolution is much higher than PET, the authors can measure more precise information of the proton‐induced positron distribution with Cerenkov light imaging technology. For this purpose, they conducted Cerenkov light imaging of induced positron distribution in proton therapy.
Methods:
First, the authors evaluated the spatial resolution of our Cerenkov light imaging system with a 22Na point source for the actual imaging setup. Then the transparent acrylic phantoms (100 × 100 × 100 mm3) were irradiated with two different proton energies using a spot scanning proton therapy system. Cerenkov light imaging of each phantom was conducted using a high sensitivity electron multiplied charge coupled device (EM‐CCD) camera.
Results:
The Cerenkov light's spatial resolution for the setup was 0.76 ± 0.6 mm FWHM. They obtained high resolution Cerenkov light images of the positron distributions in the phantoms for two different proton energies and made fused images of the reference images and the Cerenkov light images. The depths of the positron distribution in the phantoms from the Cerenkov light images were almost identical to the simulation results. The decay curves derived from the region‐of‐interests (ROIs) set on the Cerenkov light images revealed that Cerenkov light images can be used for estimating the half‐life of the radionuclide components of positrons.
Conclusions:
High resolution Cerenkov light imaging of proton‐induced positron distribution was possible. The authors conclude that Cerenkov light imaging of proton‐induced positron is promising for proton therapy.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>25370646</pmid><doi>10.1118/1.4898592</doi><tpages>6</tpages></addata></record> |
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| subjects | 60 APPLIED LIFE SCIENCES Biological material, e.g. blood, urine Haemocytometers biomedical optical imaging cameras CCD camera Cerenkov light imaging CHARGE-COUPLED DEVICES DECAY Details of cameras or camera bodies Accessories therefor DIAGRAMS Digital computing or data processing equipment or methods, specially adapted for specific applications DISTRIBUTION ELECTRONS HALF-LIFE high spatial resolution Image data processing or generation, in general image fusion image resolution INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY IRRADIATION Light medical image processing Medical image spatial resolution Monte Carlo Method Monte Carlo methods Optical Imaging PHANTOMS Phantoms, Imaging PHOTONS POINT SOURCES positron POSITRON COMPUTED TOMOGRAPHY Positron emission tomography POSITRONS proton therapy Proton Therapy - methods PROTONS radiation therapy radioisotopes SENSITIVITY SIMULATION Sodium SODIUM 22 SPATIAL RESOLUTION Therapeutic applications Therapeutic applications, including brachytherapy THERAPY Thermography VELOCITY |
| title | High resolution Cerenkov light imaging of induced positron distribution in proton therapy |
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