Aluminium induced oxidative stress results in decreased mitochondrial biogenesis via modulation of PGC-1α expression

The present investigation was carried out to elucidate a possible molecular mechanism related to the effects of aluminium-induced oxidative stress on various mitochondrial respiratory complex subunits with special emphasis on the role of Peroxisome proliferator activated receptor gamma co-activator...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-12, Vol.273 (2), p.365-380
Hauptverfasser:	Sharma, Deep Raj, Sunkaria, Aditya, Wani, Willayat Yousuf, Sharma, Reeta Kumari, Kandimalla, Ramesh J.L., Bal, Amanjit, Gill, Kiran Dip
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES ALUMINIUM Aluminum - toxicity Animals ATP Biological and medical sciences Chemical and industrial products toxicology. Toxic occupational diseases CYTOCHROME OXIDASE DNA Electron transport chain Gene Expression Regulation - drug effects HIPPOCAMPUS Male Medical sciences MESSENGER-RNA Metals and various inorganic compounds MITOCHONDRIA Mitochondrial biogenesis Mitochondrial Turnover - drug effects Mitochondrial Turnover - physiology NERVE CELLS NERVOUS SYSTEM DISEASES Neurodegeneration Neurodegenerative Diseases - metabolism Neurodegenerative Diseases - pathology Neurodegenerative Diseases - physiopathology Oxidative Stress - drug effects Oxidative Stress - physiology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RATS Rats, Wistar Reactive oxygen species RECEPTORS Toxicology Transcription Factors - biosynthesis Transcription Factors - metabolism
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