Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats

Life threatening complications from chemotherapy occur frequently in cancer survivors, however little is known about genetic risk factors. We treated male normotensive rats (WKY) and strains with hypertension (SHR) and hypertension with cardiomyopathy (SHHF) with 8 weekly doses of doxorubicin (DOX)...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-11, Vol.273 (1), p.47-57
Hauptverfasser:	Sharkey, Leslie C., Radin, M. Judith, Heller, Lois, Rogers, Lynette K., Tobias, Anthony, Matise, Ilze, Wang, Qi, Apple, Fred S., McCune, Sylvia A.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES 8,11,14-Eicosatrienoic Acid - blood Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents ARACHIDONIC ACID Arachidonic Acid - blood Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels BLOOD PRESSURE Blood Pressure - drug effects Body Weight - drug effects Cardiology. Vascular system Cardiotoxicity Cardiotoxins - toxicity Chromatography, High Pressure Liquid DOXORUBICIN Doxorubicin - toxicity EOSIN Epoxide Hydrolases - metabolism EPOXIDES Epoxyeicosatrienoic acid Genetic Predisposition to Disease Heart Heart Diseases - chemically induced Heart Diseases - genetics Heart Diseases - pathology HEART FAILURE Heart failure, cardiogenic pulmonary edema, cardiac enlargement HEMATOXYLIN HYPERTENSION Kidney - drug effects Kidney - pathology KIDNEYS Leukotriene D4 - blood Male Medical sciences METABOLISM NEOPLASMS Organ Size - drug effects Pharmacology. Drug treatments RATS Rats, Inbred SHR Rats, Inbred WKY Soluble epoxide hydrolase TOXICITY Toxicology Troponin T - blood Ventricular Function, Left - drug effects
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