A novel shogaol analog suppresses cancer cell invasion and inflammation, and displays cytoprotective effects through modulation of NF-κB and Nrf2-Keap1 signaling pathways

Natural compounds containing vanilloid and Michael acceptor moieties appear to possess anti-cancer and chemopreventive properties. The ginger constituent shogaol represents one such compound. In this study, the anti-cancer potential of a synthetic novel shogaol analog 3-phenyl-3-shogaol (3-Ph-3-SG)...

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Veröffentlicht in:	Toxicology and applied pharmacology 2013-11, Vol.272 (3), p.852-862
Hauptverfasser:	Gan, Fei-Fei, Ling, Hui, Ang, Xiaohui, Reddy, Shridhivya A., Lee, Stephanie S-H., Yang, Hong, Tan, Sock-Hoon, Hayes, John D., Chui, Wai-Keung, Chew, Eng-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals ANTIOXIDANTS Biological and medical sciences CARCINOGENESIS CARCINOMAS Catechols - chemistry Catechols - pharmacology Catechols - therapeutic use Chemoprevention CYSTEINE Cytoprotection - drug effects Cytoprotection - physiology Down-Regulation - drug effects Down-Regulation - physiology General pharmacology GENES Ginger HEK293 Cells HEME Humans INFLAMMATION Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Intracellular Signaling Peptides and Proteins - physiology Kelch-Like ECH-Associated Protein 1 LIGASES MACROPHAGES MCF-7 Cells Medical sciences Mice Michael acceptors Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Invasiveness - pathology Neoplasm Invasiveness - prevention & control NF-E2-Related Factor 2 - physiology NF-kappa B - physiology NF-κB NITRIC OXIDE Nrf2-Keap1 Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Extracts - chemistry Plant Extracts - pharmacology Plant Extracts - therapeutic use Shogaols Signal Transduction - drug effects Signal Transduction - physiology Toxicology TRANSCRIPTION FACTORS Tumors
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